ArticleLiver international : official journal of the International Association for the Study of the Liver2020
The association between etiology of hepatocellular carcinoma and race-ethnicity in Florida.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Racial and Ethnic Disparities in Outcomes in Liver Transplantation for Hepatocellular Carcinoma.The Journal of surgical research · 2026Article
- Liver Cancer Etiology in Asian Subgroups and American Indian, Black, Latino, and White Populations.JAMA network open · 2025Article
- Hepatocellular Carcinoma Etiology Drives Survival Outcomes: A Population-Based Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Article
- Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management.World journal of gastrointestinal oncology · 2024Article
- Incidence of Etiology-specific Hepatocellular Carcinoma: Diverging Trends and Significant Heterogeneity by Race and Ethnicity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Article
- Article
- Expression and diagnostic value of abnormal prothrombin and osteopontin in hepatocellular carcinoma with cirrhosis.American journal of translational research · 2024Article
- Connexin32 regulates expansion of liver cancer stem cells via the PI3K/Akt signaling pathway.Oncology reports · 2022Article
- Association of County-Level Upward Economic Mobility with Stage at Diagnosis and Receipt of Curative-Intent Treatment among Patients with Hepatocellular Carcinoma.Annals of surgical oncology · 2022Article
- Cancer Mortality in Latino Populations by Birthplace and Generation: A Complex Analysis.Journal of the National Cancer Institute · 2022Article
- Pathogenesis to management of hepatocellular carcinoma.Genes & cancer · 2022Review
- Cancer Surveillance Opportunities to Meet Prevention and Control Challenges.Journal of the National Cancer Institute · 2021Article
- Comparing Age at Cancer Diagnosis between Hispanics and Non-Hispanic Whites in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Etiology and Outcomes of Hepatocellular Carcinoma in an Ethnically Diverse Population: The Multiethnic Cohort.Cancers · 2021Article
- Cancer Mortality Disparities among Asian American and Native Hawaiian/Pacific Islander Populations in California.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- The Impact of Liver Transplantation on Hepatocellular Carcinoma Mortality in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Endometrial Cancer Type 2 Incidence and Survival Disparities Within Subsets of the US Black Population.Frontiers in oncology · 2021Article
- Cancer mortality among US blacks: Variability between African Americans, Afro-Caribbeans, and Africans.Cancer epidemiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimThe incidence of hepatocellular carcinoma (HCC) has risen considerably in the US since 1980. The main causes include metabolic disorders (NAFLD, diabetes, obesity, metabolic syndrome), alcohol-related disease (ALD) and hepatitis C and B virus infections (HCV, HBV). Etiology-specific HCC incidence rates by detailed race-ethnicity are needed to improve HCC control and prevention efforts.
methodsAll HCC cases diagnosed in Florida during 2014-2015 were linked to statewide hospital discharge data to determine etiology. Age-specific and age-adjusted rates were used to assess the intersection between etiology and detailed racial-ethnicities, including White, African American, Afro-Caribbean, Asian, Cuban, Puerto Rican and Continental Hispanic (Mexican, South and Central American).
resultsOf 3666 HCC cases, 2594 matched with discharge data. HCV was the leading cause of HCC among men and women (50% and 43% respectively), followed by metabolic disorders (25% and 37%) and ALD (16% and 9%). Puerto Rican and African American men had the highest HCV-HCC rates, 7.9 and 6.3 per 100 000 respectively. Age-specific rates for HCV-HCC peaked among baby boomers (those born in 1945-1965). Metabolic-HCC rates were highest among populations above age 70 and among Continental Hispanics. Afro-Caribbean men had high rates of HBV-HCC, whereas Puerto Rican men had high ALD-HCC.
conclusionsHCC etiology is associated with specific race/ethnicity. While HCV-related HCC rates are projected to decrease soon, HCC will continue to affect Hispanics disproportionately, based on higher rates of metabolic-HCC (and ALD-HCC) among Continental Hispanics, who demographically represent 80% of all US Hispanics. Multifaceted approaches for HCC control and prevention are needed.
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