Evidence map›Paper›PMID 32086946›Full record

ArticleTransfusion2020

In canine bacterial pneumonia circulating granulocyte counts determine outcome from donor cells.

Willard N Applefeld, Jeffrey Wang, Junfeng Sun, Benjamin M Pockros, Steven B Solomon, Jing Feng, Thomas Risoleo, Irene Cortés-Puch, Aurélie Gouél-Cheron, Harvey G Klein and 1 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transfusion, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Willard N ApplefeldCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Jeffrey WangCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Junfeng SunCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Benjamin M PockrosCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Steven B SolomonCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Jing FengCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Thomas RisoleoTufts University, Medford, Massachusetts.
Irene Cortés-PuchDivision of Pulmonary, Critical Care and Sleep Medicine, University of California Davis Medical Center, Sacramento, California.
Aurélie Gouél-CheronDepartment of Anesthesiology and Intensive Care, Bichat University Hospital, Assistance Publique-Hôpitaux de Paris, Université de Paris, Paris, France.
Harvey G KleinDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Charles NatansonCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0001-9712-2538
National Institutes of Health Clinical Center · USTufts University · USUniversité Paris Cité · FRUniversity of California Davis Medical Center · US

Funding

Effects of Adjunctive Therapy with Early Transfusion of Granulocytes in a Canine Model of S. aureus PneumoniaZIACL090051 · CLC · CLINICAL CENTER · PI SOLOMON, STEVEN · 2017 to 2020
$0k
Intramural NIH HHS ZIA CL090051NIH HHS
6 · The paper itself

Abstract

backgroundIn experimental canine septic shock, depressed circulating granulocyte counts were associated with a poor outcome and increasing counts with prophylactic granulocyte colony-stimulating factor (G-CSF) improved outcome. Therapeutic G-CSF, in contrast, did not improve circulating counts or outcome, and therefore investigation was undertaken to determine whether transfusing granulocytes therapeutically would improve outcome. STUDY DESIGN AND

methodsTwenty-eight purpose-bred beagles underwent an intrabronchial Staphylococcus aureus challenge and 4 hours later were randomly assigned to granulocyte (40-100 × 10

resultsGranulocyte transfusion significantly expanded the low circulating counts for hours compared to septic controls but was not associated with significant mortality benefit (1/14, 7% vs. 2/14, 14%, respectively; p = 0.29). Septic animals with higher granulocyte count at 4 hours (median [interquartile range] of 3.81 3.39-5.05] vs. 1.77 [1.25-2.50]) had significantly increased survival independent of whether they were transfused with granulocytes. In a subgroup analysis, animals with higher circulating granulocyte counts receiving donor granulocytes had worsened lung injury compared to septic controls. Conversely, donor granulocytes decreased lung injury in septic animals with lower counts.

conclusionDuring bacterial pneumonia, circulating counts predict the outcome of transfusing granulocytes. With low but normal counts, transfusing granulocytes does not improve survival and injures the lung, whereas for animals with very low counts, but not absolute neutropenia, granulocyte transfusion improves lung function.

Indexed as

AnimalsDisease Models, AnimalDogsGranulocyte Colony-Stimulating FactorGranulocytesLeukocyte CountLeukocyte TransfusionLung InjuryPneumonia, BacterialStaphylococcus aureusTissue DonorsTreatment OutcomeGranulocyte Colony-Stimulating Factor

Identifiers

PMID32086946
PMCPMC10802110
OpenAlexW3006774870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.