Evidence map›Paper›PMID 32086864›Full record

ArticleObesity (Silver Spring, Md.)2020

Measures of Adipose Tissue Redistribution and Atherosclerotic Coronary Plaque in HIV.

Milana Bogorodskaya, Kathleen V Fitch, Michael Lu, Martin Torriani, Markella V Zanni, Sara E Looby, Sanjna Iyengar, Virginia A Triant, Steven K Grinspoon, Suman Srinivasa and 1 more

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Milana BogorodskayaDivision of Infectious Disease, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Kathleen V FitchMetabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Michael LuDivision of Cardiovascular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Martin TorrianiDivision of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-6255-6413
Markella V ZanniMetabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Sara E LoobyMetabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Sanjna IyengarMetabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Virginia A TriantDivision of Infectious Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Steven K GrinspoonMetabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Suman Srinivasa *Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Janet Lo *Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-5678-6140
Harvard University · USBeth Israel Deaconess Medical Center · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI HALL, JANET E · 1985 to 2008
$37.4M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Enhancing cardiovascular risk estimation in individuals aging with HIV/HCV co-infectionR01AG062393 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI TRIANT, VIRGINIA ATHENA · 2019 to 2023
$4.5M
Optimizing Cardiovascular Risk Prediction in HIVR01HL132786 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI D'AGOSTINO, RALPH B, TRIANT, VIRGINIA ATHENA · 2017 to 2020
$3.5M
Physiologic Investigation of the Renin-Angiotensin-Aldosterone System to Understand Arterial Inflammation in HIVK23HL136262 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SRINIVASA, SUMAN · 2017 to 2021
$960k
Atherosclerosis and Inflammation in HIV DiseaseK23HL092792 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LO, JANET · 2008 to 2012
$705k
Subclinical Coronary Atherosclerosis in HIV-Infected PatientsF32HL088991 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LO, JANET · 2007 to 2007
$12k
NCATS NIH HHS UL1 TR001102NCRR NIH HHS M01 RR001066NCRR NIH HHS UL1 RR025758NHLBI NIH HHS F32 HL088991NHLBI NIH HHS K23 HL092792NHLBI NIH HHS K23 HL136262NHLBI NIH HHS R01 HL132786NIA NIH HHS R01 AG062393NIDDK NIH HHS P30 DK040561NIH HHS F32 HL088991NIH HHS K23 HL092792NIH HHS K23 HL136262NIH HHS M01 RR01066NIH HHS P30 045061NIH HHS UL1 RR025758NIH HHS UL1 TR001102
6 · The paper itself

Abstract

objectivePeople with HIV (PWH) who are well treated on antiretroviral therapy remain at increased risk for body composition changes, including increased visceral adipose tissue (VAT) and reduced subcutaneous adipose tissue (SAT), as well as increased cardiovascular disease (CVD). The relationship between adipose compartments and coronary disease is not well understood among PWH.

methodsA total of 148 PWH and 68 uninfected individuals without CVD were well phenotyped for VAT and SAT via single-section abdominal computed tomography (CT) at L4. Coronary artery calcium (CAC) score was assessed by noncontrast cardiac CT and coronary plaque composition by coronary CT angiography.

resultsIncreased VAT was significantly related to increased presence of plaque (OR, 1.55 per 100 cm

conclusionsFat redistribution phenotyping by simultaneous quantification of VAT and SAT as independent measures could help identify those PWH at higher risk for CVD.

Indexed as

Adipose TissueCoronary Artery DiseaseFemaleHIV InfectionsHumansMaleMiddle AgedPlaque, Atherosclerotic

Identifiers

PMID32086864
PMCPMC7093223
OpenAlexW3007818871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.