Evidence map›Paper›PMID 32086845›Full record

ArticleMagnetic resonance in medicine2020

A metabolite-specific 3D stack-of-spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1-

Shuyu Tang, Robert Bok, Hecong Qin, Galen Reed, Mark VanCriekinge, Romelyn Delos Santos, William Overall, Juan Santos, Jeremy Gordon, Zhen Jane Wang and 2 more

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  6. Data Format Standardization and DICOM Integration for HyperpolarizedJournal of imaging informatics in medicine · 2024
    Article
  7. A pharmacokinetic model for hyperpolarizedMagnetic resonance in medicine · 2024
    Article
  8. Article
  9. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  10. Article
  11. HyperpolarizedMagnetic resonance in medicine · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Clinical translation of hyperpolarizedMagnetic resonance in medicine · 2022
    Article
  16. Denoising of hyperpolarizedMagnetic resonance in medicine · 2021
    Article
  17. CardiacMagnetic resonance in medicine · 2021
    Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Shuyu TangUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, CA, USA.ORCID 0000-0002-9911-482X
Robert BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Hecong QinUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, CA, USA.
Galen ReedHeartVista, Los Altos, CA, USA.
Mark VanCriekingeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Romelyn Delos SantosDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
William OverallDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Juan SantosDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Jeremy GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Zhen Jane WangUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, CA, USA.
Daniel B VigneronUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, CA, USA.
Peder E Z LarsonUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, CA, USA.
University of California, San Francisco · USHeartVista (United States) · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Supplement for Development and Translation of Specialized Hyperpolarized C-13 MRI Methods for Alzheimer's DiseaseU01EB026412 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORDON, JEREMY WILLIAM, VIGNERON, DANIEL B · 2019 to 2023
$6.6M
Hyperpolarized C-13 Diffusion MRI Measures of Cellular Transport and MetabolismR01EB016741 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL · 2014 to 2017
$2.0M
NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB016741NIBIB NIH HHS U01 EB026412
6 · The paper itself

Abstract

purposeThe balanced steady-state free precession sequence has been previously explored to improve the efficient use of nonrecoverable hyperpolarized

methodsSimulations were performed to evaluate the spectral response of the MS-3DSSFP sequence. Thermal

resultsSimulations, phantom, and in vivo studies demonstrate that the MS-3DSSFP sequence achieved spectrally selective excitation on lactate while minimally perturbing other metabolites. Compared with MS-GRE sequences, the MS-3DSSFP sequence showed approximately a 2.5-fold SNR improvement for lactate imaging in rat kidneys, prostate tumors in a mouse model, and human kidneys.

conclusionsImproved lactate imaging using the MS-3DSSFP sequence in hyperpolarized [1-

Indexed as

Lactic AcidPyruvic AcidAnimalsCarbon IsotopesHumansImaging, Three-DimensionalMagnetic Resonance ImagingMalePhantoms, ImagingCarbon IsotopesLactic AcidPyruvic Acid13CbSSFPhyperpolarizedlactatemetabolic imagingMRIpyruvate

Identifiers

PMID32086845
PMCPMC7927572
OpenAlexW3008452296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.