ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2020
Inhibition of quorum sensing-associated virulence factors and biofilm formation in Pseudomonas aeruginosa PAO1 by Mycoleptodiscus indicus PUTY1.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 28 citations in OpenAlex.
- Exploration of anti-quorum sensing properties of eicosyl heptafluorobutyrate against a clinical strain of Pseudomonas aeruginosa.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- A Systematic Hierarchical Virtual Screening Model for RhlR Inhibitors Based on PCA, Pharmacophore, Docking, and Molecular Dynamics.International journal of molecular sciences · 2024Article
- Inhibition of Pseudomonas aeruginosa quorum sensing by methyl gallate from Mangifera indica.Scientific reports · 2023Article
- 3-(Bromoacetyl) coumarin is a potential therapeutic agent against neonatal sepsis-associated Pseudomonas extremorientalis.Archives of microbiology · 2023Article
- Effect of traditional Chinese medicine monomers interfering with quorum-sensing on virulence factors of extensively drug-resistantFrontiers in pharmacology · 2023Article
- Effect of Biogenic Silver Nanoparticles on the Quorum-Sensing System ofMicroorganisms · 2022Article
- Phytotoxicity Optimization of Fungal Metabolites Produced by Solid and Submerged Fermentation and its Ecotoxicological Effects.Applied biochemistry and biotechnology · 2022Article
- The Impact of an Efflux Pump Inhibitor on the Activity of Free and Liposomal Antibiotics againstPharmaceutics · 2021Article
- Subinhibitory Concentrations of Biogenic Silver Nanoparticles Affect Motility and Biofilm Formation inFrontiers in cellular and infection microbiology · 2021Article
- Quorum Sensing Inhibiting Activity of Cefoperazone and Its Metallic Derivatives onFrontiers in cellular and infection microbiology · 2021Article
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6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas aeruginosa is the second most emerging multidrug-resistant, opportunistic pathogen after Acinetobacter baumannii that poses a threat in nursing homes, hospitals, and patients who need devices such as ventilators and blood catheters. Its ability to form quorum sensing-regulated virulence factors and biofilm makes it more resistant to top most therapeutic agents such as carbapenems and next-generation antibiotics. In the current study, we studied the quorum quenching potential of secondary metabolites of Mycoleptodiscus indicus PUTY1 strain. In vitro observation showed a mitigation in virulence factors such as rhamnolipids, protease, elastase pyocyanin, exopolysaccharides, and hydrogen cyanide gas. Furthermore, a significant reduction in the motility such as swimming, swarming, twitching, and inhibition in biofilm formation by Pseudomonas aeruginosa PAO1 was observed. Results of in vitro studies were further confirmed by in silico studies through docking and molecular dynamic simulation of GC-MS-detected compounds of Mycoleptodiscus indicus employing LasR and RhlR proteins. Both in vitro and in silico observations indicate a new alternative approach for combating virulence of Pseudomonas aeruginosa by targeting its protein receptors LasR and RhlR. Graphical abstract.
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