Evidence map›Paper›PMID 32086692›Full record

ArticleThe protein journal2020

The Effects of Paclitaxel in the Combination of Diamond Nanoparticles on the Structure of Human Serum Albumin (HSA) and Their Antiproliferative Role on MDA-MB-231cells.

Azadeh Hekmat, Fariba Salavati, Saeed Hesami Tackallou

Abstract read
PubMed Publisher
In one paragraph

Article in The protein journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Azadeh HekmatDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. hekmat@ut.ac.ir.ORCID 0000-0003-0123-1575
Fariba SalavatiDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Saeed Hesami TackallouDepartment of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Islamic Azad University, Science and Research Branch · IRIslamic Azad University Central Tehran Branch · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the interactions of anti-cancer agents with blood constituents, in particular with human serum albumin (HSA) may have a major impact on drug pharmacology, the present study designed to provide a fundamental understanding of the interaction of nanodiamonds (NDs) together with paclitaxel (PTX) with HSA in detail for the first time. The UV-Vis, steady-state fluorescence, far-UV CD and zeta potential results displayed that PTX + NDs could form a complex with HSA. Additionally, the values of binding constants and ΔG

Indexed as

Antineoplastic Agents, PhytogenicCell Line, TumorCell ProliferationCell SurvivalDrug CombinationsDrug SynergismHumansHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsInhibitory Concentration 50NanodiamondsPaclitaxelProtein BindingSerum Albumin, HumanAntineoplastic Agents, PhytogenicDrug CombinationsNanodiamondsPaclitaxelSerum Albumin, HumanDiamond nanoparticles (NDs)Human serum albumin (HSA)MDA-MB-231cellsPaclitaxel (PTX)SpectroscopyZeta potential

Identifiers

PMID32086692
OpenAlexW3009524133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.