ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020
The influence of statins on the risk of post-stroke epilepsy.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The prevention of stroke by statins: A meta-analysis.Medicine · 2022Pooled it
- From Acute Symptomatic Seizures to Post-Stroke Epilepsy: A Narrative Review of Diagnosis and Management.Journal of clinical medicine · 2026Review
- Association of atherogenic index of plasma and post-stroke epilepsy in patients with ischemic stroke: a multicenter retrospective study in China.Therapeutic advances in neurological disorders · 2026Article
- Neuroprotective effects of Simvastatin against alcohol-induced oxidative stress and neurodegeneration in the Hippocampus of adolescent mice.Metabolic brain disease · 2025Article
- Statins' protective effects on focal epilepsy are independent of LDL-C.Epilepsia open · 2025Article
- Role of CD36 in central nervous system diseases.Neural regeneration research · 2024Review
- Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review.Iranian journal of medical sciences · 2023Review
- Statins as antiepileptogenic drugs: Analyzing the evidence and identifying the most promising statin.Epilepsia · 2022Review
- Clinical Characteristics and Gene Mutation Analysis of Poststroke Epilepsy.Contrast media & molecular imaging · 2022Article
- The influence of statin withdrawal and adherence on stroke outcomes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management.Drugs & aging · 2021Review
- Predictive Values of the SeLECT Score and IL-1β for Post-Stroke Epilepsy.Neuropsychiatric disease and treatment · 2021Article
- Antiepileptic Drug Management in Acute Ischemic Stroke: Are Vascular Neurologists Utilizing Electroencephalograms? An Observational Cohort Study.BioMed research international · 2020Observational
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, statins are widely used for secondary prevention of stroke due to their pleiotropic neuroprotective effects. Epilepsy is a common complication of cerebrovascular diseases. The purpose of this study was to evaluate the effect of statin therapy on the occurrence of post-stroke epilepsy (PSE).
methodsIn this prospective cohort study, patients who suffered an ischemic stroke and without history of epilepsy before stroke were enrolled. At baseline, patients were classified according to the particularities of statin therapy. Statin use onset and adherence to treatment were registered as well. After a follow-up period of 1 year, we assessed the occurrence of seizures and PSE.
resultsAmong the 477 patients included in our cohort, there were 91 (19.1%) patients without statins, 160 (33.5%) with simvastatin 20 mg, 180 (37.7%) with simvastatin 40 mg, and 46 (9.6%) with high-potency statins. Overall, PSE emerged in 53 (11.1%) patients. PSE was significantly more prevalent among those who did not receive statins and those with lower doses of simvastatin. Acute onset of statin use was associated with reduced odds of having PSE.
conclusionAdequate treatment with statins after stroke may lower the risk of PSE.
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