Evidence map›Paper›PMID 32086598›Full record

SynthesisCurrent neurology and neuroscience reports2020

State of the Evidence Traffic Lights 2019: Systematic Review of Interventions for Preventing and Treating Children with Cerebral Palsy.

Iona Novak, Catherine Morgan, Michael Fahey, Megan Finch-Edmondson, Claire Galea, Ashleigh Hines, Katherine Langdon, Maria Mc Namara, Madison Cb Paton, Himanshu Popat and 9 more

16 registry-linked trialsAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current neurology and neuroscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 16 registered trials, which are not on this map. Cited by 425 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
425citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04778930 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effectiveness of Physical Therapy for Improving the Functionality, Gait and Participation in the Environment in Children and Adolescents With Cerebral Palsy: Randomized Clinical Trial

TypeinterventionalSponsorUniversity of AlcalaRan2022 to 2023Enrolled66ConditionsPhysical Therapy, Cerebral Palsy, Therapeutic Education, TelehealthArmsPhysical Therapy, THERAPEUTIC EDUCATION PROGRAM
NCT05131724 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effectiveness of Virtual Reality on Functional Mobility During Treadmill Training in Children With Cerebral Palsy: a Randomized Clinical Trial (VirtWalkCP Project)

TypeinterventionalSponsorUniversity of Vic - Central University of CataloniaRan2022 to 2025Enrolled30ConditionsCerebral Palsy, SpasticArmsTreadmill training with virtual reality, Treadmill training
NCT05464004 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Nintendo Wii Balance Board in Children With Cerebral Palsy

TypeinterventionalSponsorRiphah International UniversityRan2021 to 2022Enrolled24ConditionsBalance Problem, Cerebral PalsyArmsNintendo Wii balance board
NCT05670522 nacompletednot on this map

Transcranial Direct Current Stimulation Versus Virtual Reality on Gait in Children With Spastic Diplegia

TypeinterventionalSponsorBeni-Suef UniversityRan2020 to 2021Enrolled40ConditionsCerebral PalsyArmsTranscranial direct current stimulation, Virtual reality
NCT05740605 narecruitingnot on this mapstarted 2023, after this paper: background citation

Implementation of a HABIT-ILE at Home Intervention for Children With Bilateral Cerebral Palsy: a Non-inferiority Randomized Controlled Trial

TypeinterventionalSponsorUniversité Catholique de LouvainRan2023 to 2027Enrolled48ConditionsCerebral PalsyArmsHand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE), Hand-Arm Bimanual Intensive Therapy Including Lower Extremities at home, Follow-up Hand-Arm Bimanual Intensive Therapy Including Lower Extremities, Usual Care
NCT06003868 nacompletednot on this mapstarted 2023, after this paper: background citation

Investigation of the Effect of Hippotherapy Simulator on Balance and Walking in Children With Spastic Diplegia Cerebral Palsy

TypeinterventionalSponsorUskudar UniversityRan2023 to 2023Enrolled40ConditionsCerebral Palsy, Balance, Distorted, Walking, DifficultyArmstraditional physiotherapy, hippotherapy-assisted physiotherapy
NCT06109129 narecruitingnot on this mapstarted 2023, after this paper: background citation

Investıgatıon Of The Effectıveness Of The Mollıı Suıt In Chıldren Wıth Ambulatory Cerebral Palsy: A Double-Blınd Randomızed Controlled Study

TypeinterventionalSponsorKastamonu UniversityRan2023 to 2025Enrolled32ConditionsCerebral Palsy, Spasticity, MuscleArmsEXOPULSE Mollii Suit
NCT06185504 naterminatednot on this mapstarted 2022, after this paper: background citation

Comparison of Intermittent Oro-Esophageal Tube Feeding Versus Persistent Nasogastric Tube Feeding in Infants With Cerebral Palsy and Dysphagia: A Randomized Controlled Study

TypeinterventionalSponsorZeng ChanghaoRan2022 to 2023Enrolled80ConditionsCerebral PalsyArmssystemic therapy, Intermittent Oro-Esophageal Tube Feeding, Persistent Nasogastric Tube Feeding
NCT06330311 nacompletednot on this mapstarted 2024, after this paper: background citation

Effectiveness of Whole-Body Vibration on Lower Limb Motor Function and Spasticity in Children With Spastic Cerebral Palsy

TypeinterventionalSponsorUniversidad Complutense de MadridRan2024 to 2024Enrolled30ConditionsSpastic Cerebral Palsy, Physical Therapy Modalities, Vibration, ExposureArmsPhysiotherapy
NCT06571929 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Task-Specific Training in Augmented Reality Context (INTERACT Protocol) on Upper Limb Function and Activities in Children With Spastic Cerebral Palsy: A Randomized Controlled Trial

TypeinterventionalSponsorUniversidade Federal de Sao CarlosRan2024 to 2026Enrolled34ConditionsCerebral Palsy, SpasticArmsINTERACT
NCT06627049 recruitingnot on this mapstarted 2024, after this paper: background citation

Virtual Reality Implantation in Paediatric Rehabilitation (IMPLANT-VR4 CHILD)

TypeobservationalSponsorFondation IldysRan2024 to 2025Enrolled39ConditionsChildren with Undergoing RehabilitationArmsFocus group, Implementing facilitating strategies, Interviews
NCT06702709 nacompletednot on this mapstarted 2024, after this paper: background citation

EFFECTS of INSTRUMENT-ASSISTED SOFT TISSUE MOBILIZATION VS. NEURODEVELOPMENTAL THERAPY on MOTOR FUNCTION in CHILDREN with GMFCS LEVEL I and II SPASTIC DIPLEGIC CEREBRAL PALSY

TypeinterventionalSponsorZiauddin UniversityRan2024 to 2024Enrolled60ConditionsDiplegic Spastic Cerebral PalsyArmsInstrument Assisted Soft Tissue Mobilization, Neurodevelopmental Therapy
NCT06853717 nacompletednot on this mapstarted 2022, after this paper: background citation

Implementation of Therapy Together With Early Childhood Intervention

TypeinterventionalSponsorTexas Scottish Rite Hospital for ChildrenRan2022 to 2023Enrolled5ConditionsUnilateral Cerebral PalsyArmsTherapy Together
NCT07148856 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of a Combination of Myofascial Release Technique to Conventional Physiotherapy Program on Functional Outcomes in Pediatric Cerebral Palsy Post Achilles Tendon Surgery in the Gaza Strip

TypeinterventionalSponsorIsmail K. Al-QudraRan2025 to 2025Enrolled40ConditionsCerebral Palsy Achilles Tendon Contracture Achilles Tendon SurgeryArmsConventional Physiotherapy, Myofascial Release Technique
NCT07311018 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Effects of Neuromuscular Electrical Stimulation and Leap Motion-Based Exercises on Hand Function Parameters in Cerebral Palsy

TypeinterventionalSponsorMedipol UniversityRan2026 to 2026Enrolled30ConditionsCerebral Palsy (CP)ArmsLeap Motion-Based Exercise Program, NMES, Conventional Exercise Program
NCT07369193 recruitingnot on this mapstarted 2026, after this paper: background citation

Immersive AOT: Multisensory Stimulation and Neurophysiological Correlates - A Pilot Study

TypeobservationalSponsorIRCCS Fondazione Stella MarisRan2026 to 2027Enrolled40ConditionsCerebral Palsy (CP), CP (Cerebral Palsy), Motor Imagery, Action Observation
3 · Its place in the literature

Who cites it

425 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  12. Effects of various exercise interventions on motor function in cerebral palsy patients: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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365 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Iona NovakCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia. inovak@cerebralpalsy.org.au.
Catherine MorganCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Michael FaheyDepartment of Paediatric Neurology, Monash Health, Clayton, Victoria, Australia.
Megan Finch-EdmondsonCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Claire GaleaCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Ashleigh HinesCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Katherine LangdonDepartment of Paediatric Rehabilitation, Kids Rehab WA, Perth Children's Hospital, Perth, Australia.
Maria Mc NamaraCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Madison Cb PatonCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Himanshu PopatCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Benjamin ShoreDepartment of Orthopedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Amanda KhamisCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Emma StantonCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Olivia P FinemoreCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Alice TricksCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Anna Te VeldeCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.
Leigha DarkAllied and Public Helath, Faculty of Health Sciences, Western Sydney University, Sydney, New South Wales, Australia.
Natalie MortonAllied and Public Helath, Faculty of Health Sciences, Western Sydney University, Sydney, New South Wales, Australia.
Nadia BadawiCerebral Palsy Alliance Research Institute, Discipline of Child & Adolescent Health, Faculty of Medicine & Health, The University of Sydney, PO Box 6427, Frenchs Forest, Sydney, NSW, 2086, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewCerebral palsy is the most common physical disability of childhood, but the rate is falling, and severity is lessening. We conducted a systematic overview of best available evidence (2012-2019), appraising evidence using GRADE and the Evidence Alert Traffic Light System and then aggregated the new findings with our previous 2013 findings. This article summarizes the best available evidence interventions for preventing and managing cerebral palsy in 2019. RECENT

findingsEffective prevention strategies include antenatal corticosteroids, magnesium sulfate, caffeine, and neonatal hypothermia. Effective allied health interventions include acceptance and commitment therapy, action observations, bimanual training, casting, constraint-induced movement therapy, environmental enrichment, fitness training, goal-directed training, hippotherapy, home programs, literacy interventions, mobility training, oral sensorimotor, oral sensorimotor plus electrical stimulation, pressure care, stepping stones triple P, strength training, task-specific training, treadmill training, partial body weight support treadmill training, and weight-bearing. Effective medical and surgical interventions include anti-convulsants, bisphosphonates, botulinum toxin, botulinum toxin plus occupational therapy, botulinum toxin plus casting, diazepam, dentistry, hip surveillance, intrathecal baclofen, scoliosis correction, selective dorsal rhizotomy, and umbilical cord blood cell therapy. We have provided guidance about what works and what does not to inform decision-making, and highlighted areas for more research.

Indexed as

Cerebral PalsyChildHumansCerebral palsyEvidence basedGRADESystematic reviewTraffic light system

Identifiers

PMID32086598
PMCPMC7035308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

and 10 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.