ArticleEuropean radiology2020
Evaluation of MR elastography as a response parameter for transarterial chemoembolization of colorectal liver metastases.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Compact Tabletop Magnetic Resonance Elastography for Mapping Soft Tissue Viscoelasticity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Relationship between survival outcomes in patients with colorectal liver metastasis undergoing hepatectomy and significance of fibrotic markers for liver injury assessment.Translational cancer research · 2025Article
- Viscoelastic properties of colorectal liver metastases reflect tumour cell viability.Journal of translational medicine · 2024Article
- Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer.Cancer biology & medicine · 2023Review
- Elastic modulus-reflected liver lesion stiffness relates to worse prognosis in pancreatic cancer patients with liver metastasis.World journal of surgical oncology · 2023Article
- Response comparison of PLC and SLC with magnetic resonance elastography after TACE.Scientific reports · 2022Article
- Early effect ofEuropean radiology · 2021Article
- The Advance of Magnetic Resonance Elastography in Tumor Diagnosis.Frontiers in oncology · 2021Review
- Value of shear wave elastography with maximal elasticity in differentiating benign and malignant solid focal liver lesions.World journal of gastroenterology · 2020Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate magnetic resonance elastography (MRE) as a response parameter in patients who received transarterial chemoembolization (TACE) for the treatment of colorectal liver metastases. MATERIALS AND
methodsForty-two patients (29 male patients; mean age, 61.5 years; range, 41-84 years) with repeated TACE therapy of colorectal liver metastases underwent on average 2 repetitive magnetic resonance imaging (MRI) and MRE exams in 4- to 6-week intervals using a 1.5-T scanner. MRE-based liver stiffness measurements were performed in normal liver parenchyma and in metastatic lesions. Moreover, the size of the liver metastases was assessed during treatment and compared with the results of the MRE analysis.
resultsLiver metastases showed a significantly higher degree of stiffness compared with the normal liver parenchyma (p < 0.001). However, only a weak correlation was found between the lesion size and stiffness (r = - 0.32, p = 0.1). MRE analysis revealed an increase in stiffness of the colorectal liver metastases from 4.4 to 7.1 kPa after three cycles of TACE (p < 0.001). Also, the mean size of the metastases decreased from 17.0 to 11.3 cm
conclusionIn conclusion, MRE showed a significant change in stiffness and size of liver metastases. Therefore, MRE may provide an added value for an evaluation of treatment response in patients with colorectal liver metastases undergoing TACE. KEY POINTS: • MRE showed an increase in stiffness of the colorectal liver metastases during TACE therapy. • Liver metastases showed a significantly higher degree of stiffness compared with the normal liver parenchyma. • However, only a weak correlation was found between the lesion size and stiffness.
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