Evidence map›Paper›PMID 32086540›Full record

ArticlePsychopharmacology2020

Decreased sensitivity in adolescent versus adult rats to the antidepressant-like effects of cannabidiol.

Cristian Bis-Humbert, Rubén García-Cabrerizo, M Julia García-Fuster

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Cristian Bis-HumbertIUNICS, University of the Balearic Islands, Cra. de Valldemossa km 7.5, E-07122, Palma, Spain.
Rubén García-CabrerizoIUNICS, University of the Balearic Islands, Cra. de Valldemossa km 7.5, E-07122, Palma, Spain.
M Julia García-FusterIUNICS, University of the Balearic Islands, Cra. de Valldemossa km 7.5, E-07122, Palma, Spain. j.garcia@uib.es.ORCID http://orcid.org/0000-0002-9177-3775
Health Research Institute of the Balearic Islands · ESUniversity College Cork · IE

Funding

IdISBa, GOIB "TECH" from project "TALENT PLUS Construint Salut, Generant Valor"Instituto de Salud Carlos III RD16/0017/0010Ministerio de Sanidad, Servicios Sociales e Igualdad 2016/002
6 · The paper itself

Abstract

rationaleCannabidiol is a non-psychoactive phytocannabinoid with great therapeutic potential in diverse psychiatric disorders; however, its antidepressant potential has been mainly ascertained in adult rats.

objectivesTo compare the antidepressant-like response induced by cannabidiol in adolescent and adult rats and the possible parallel modulation of hippocampal neurogenesis.

methodsMale Sprague-Dawley rats were repeatedly treated with cannabidiol (3, 10, and 30 mg/kg) or vehicle (1 mL/kg) during adolescence (postnatal days, PND 27-33) or adulthood (PND 141-147) and exposed to 3 consecutive tests (forced swim, open field, two-bottle choice) that quantified behavioral despair, anxiety, and sucrose intake respectively.

resultsCannabidiol induced differential effects depending on the age and dose administered, with a decreased sensitivity observed in adolescent rats: (1) cannabidiol (30 mg/kg) decreased body weight only in adult rats; (2) cannabidiol ameliorated behavioral despair in adolescent and adult rats, but with a different dose sensitivity (10 vs. 30 mg/kg), and with a different extent (2 vs. 21 days post-treatment); (3) cannabidiol did not modulate anxiety-like behavior at any dose tested in adolescent or adult rats; and (4) cannabidiol increased sucrose intake in adult rats.

conclusionsOur findings support the notion that cannabidiol exerts antidepressant- and anorexigenic-like effects in adult rats and demonstrate a decreased potential when administered in adolescent rats. Moreover, since cannabidiol did not modulate hippocampal neurogenesis (cell proliferation and early neuronal survival) in adolescent or adult rats, the results revealed potential antidepressant-like effects induced by cannabidiol without the need of regulating hippocampal neurogenesis.

Indexed as

Age FactorsAnimalsAntidepressive AgentsCannabidiolDepressionHippocampusMaleNeurogenesisRatsRats, Sprague-DawleySwimmingAntidepressive AgentsCannabidiolAgeAntidepressantCannabidiolHippocampusNeurogenesisRat

Identifiers

PMID32086540
OpenAlexW3007168762

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.