ArticleThe Journal of biological chemistry2020
Biochemical characterization of acyl activating enzymes for side chain moieties of Taxol and its analogs.
Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Oscillatory dynamics in paclitaxel-proteinoid networks.Discover molecules · 2026Article
- Article
- Post-genomic illumination of paclitaxel biosynthesis.Nature plants · 2024Review
- Plants against cancer: towards green Taxol production through pathway discovery and metabolic engineering.aBIOTECH · 2024Review
- Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol.Nature communications · 2024Article
- Disruption of theInternational journal of molecular sciences · 2024Article
- Article
- A peroxisomal heterodimeric enzyme is involved in benzaldehyde synthesis in plants.Nature communications · 2022Article
- Characterization of a Cytosolic Acyl-Activating Enzyme Catalyzing the Formation of 4-Methylvaleryl-CoA for Pogostone Biosynthesis in Pogostemon Cablin.Plant & cell physiology · 2021Article
- Taxanes and taxoids of the genus Taxus - A comprehensive inventory of chemical diversity.Phytochemistry · 2021Review
- Recent Advances in Metabolic Engineering, Protein Engineering, and Transcriptome-Guided Insights Toward Synthetic Production of Taxol.Frontiers in bioengineering and biotechnology · 2021Review
- 4-Coumaroyl-CoA ligases in the biosynthesis of the anti-diabetic metabolite montbretin A.PloS one · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Taxol (paclitaxel) is a very widely used anticancer drug, but its commercial sources mainly consist of stripped bark or suspension cultures of members of the plant genus Taxus. Taxol accumulates as part of a complex mixture of chemical analogs, termed taxoids, which complicates its production in pure form, highlighting the need for metabolic engineering approaches for high-level Taxol production in cell cultures or microbial hosts. Here, we report on the characterization of acyl-activating enzymes (AAEs) that catalyze the formation of CoA esters of different organic acids relevant for the
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.