ArticleThe Plant cell2020
Chimeric Activators and Repressors Define HY5 Activity and Reveal a Light-Regulated Feedback Mechanism.
Article in The Plant cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 159 citations in OpenAlex.
- Larix gmelinii UGPase enhances vegetative growth in transgenic poplar through an HYH-mediated positive feedback loop.Plant cell reports · 2026Article
- Twenty-five years of photobodies: formation, composition, and the 2-compartment logic of phytochrome B signaling.Plant physiology · 2026Review
- Natural variation links seedling hypocotyl growth with water loss in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Light regulates tomato fruit metabolome via SlDML2-mediated global DNA demethylation.Journal of integrative plant biology · 2026Article
- Genome-scale transcriptome augmentation during Arabidopsis thaliana photomorphogenesis.Nature communications · 2025Article
- Transcriptional dynamics and chromatin accessibility in the regulation of shade-responsive genes in Arabidopsis.Genome biology · 2025Article
- The Gene Expression of the Transcription Factors HY5 and HFR1 Is Involved in the Response ofBiology · 2025Article
- A PIF-SAUR module safeguards hypocotyl elongation from ABA inhibition in the dark.Science advances · 2025Article
- Many transcription factor families have evolutionarily conserved binding motifs in plants.Plant physiology · 2025Article
- The CRY1-COP1-HY5 axis mediates blue-light regulation of Arabidopsis thermotolerance.Plant communications · 2025Article
- Shedding light on iron nutrition: exploring intersections of transcription factor cascades in light and iron deficiency signaling.Journal of experimental botany · 2025Review
- Unequal Genetic Redundancies Among MYC bHLH Transcription Factors Underlie Seedling Photomorphogenesis in Arabidopsis.Plant direct · 2025Article
- Optimized DNA affinity purification sequencing determines relative binding affinity of transcription factors.Biology methods & protocols · 2025Article
- Spatiotemporal bifurcation of HY5-mediated blue-light signaling regulates wood development during secondary growth.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Phytochrome C and Low Temperature Promote the Protein Accumulation and Red-Light Signaling of Phytochrome D.Plant & cell physiology · 2024Article
- Temporal and spatial frameworks supporting plant responses to vegetation proximity.Plant physiology · 2024Article
- bZIP Transcription Factors: Structure, Modification, Abiotic Stress Responses and Application in Plant Improvement.Plants (Basel, Switzerland) · 2024Review
- Nutrient levels control root growth responses to high ambient temperature in plants.Nature communications · 2024Article
- Genetic regulation of self-organizing azimuthal canopy orientations and their impacts on light interception in maize.The Plant cell · 2024Article
- Transcriptional Regulation and Gene Mapping of Internode Elongation and Late Budding in the Chinese Cabbage MutantPlants (Basel, Switzerland) · 2024Article
12 more citing papers are in PubMed but not listed here.
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6 authors at 1 institution in 1 country.
Funding
Abstract
The first exposure to light marks a crucial transition in plant development. This transition relies on the transcription factor HY5 controlling a complex downstream growth program. Despite its importance, its function in transcription remains unclear. Previous studies have generated lists of thousands of potential target genes and competing models of HY5 transcription regulation. In this work, we carry out detailed phenotypic and molecular analysis of constitutive activator and repressor HY5 fusion proteins. Using this strategy, we were able to filter out large numbers of genes that are unlikely to be direct targets, allowing us to eliminate several proposed models of HY5's mechanism of action. We demonstrate that the primary activity of HY5 is promoting transcription and that this function relies on other, likely light-regulated, factors. In addition, this approach reveals a molecular feedback loop via the COP1/SPA E3 ubiquitin ligase complex, suggesting a mechanism that maintains low HY5 in the dark, primed for rapid accumulation to reprogram growth upon light exposure. Our strategy is broadly adaptable to the study of transcription factor activity. Lastly, we show that modulating this feedback loop can generate significant phenotypic diversity in both Arabidopsis (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.