Evidence map›Paper›PMID 32086204›Full record

ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2020

Validation of Ultrasound Super-Resolution Imaging of Vasa Vasorum in Rabbit Atherosclerotic Plaques.

Qiyang Chen, Jaesok Yu, Lyudmila Lukashova, Joseph D Latoche, Jianhui Zhu, Linda Lavery, Konstantinos Verdelis, Carolyn J Anderson, Kang Kim

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07645599 (Microvasculature Ultrasound Super-resolution in Transplant Delayed Graft Function), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07645599 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Microvasculature Ultrasound Super-resolution in Transplant Delayed Graft Function

Typeobservational_patient_registrySponsorRoderick TanRan2026 to 2028Enrolled40ConditionsEnd Stage Chronic Renal Failure, Renal Transplant, Microvascular Changes, Microvascular CirculationArmsUltrasound contrast agent (Contrast-enhanced ultrasound), Optison (Perflutren Protein-Type A Microspheres Injectable Suspension), Lumason® contrast agent, DEFINITY®
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Qiyang Chen
Jaesok Yu
Lyudmila Lukashova
Joseph D Latoche
Jianhui Zhu
Linda Lavery
Konstantinos Verdelis
Carolyn J Anderson
Kang Kim
University of Pittsburgh · USUniversity of Pittsburgh Medical Center · US

Funding

High-resolution ultrasound in-vivo animal imaging system-Vevo2100S10RR027383 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KIM, KANG · 2010 to 2010
$498k
Request for a high resolution microcomputed tomography system for the School of Dental Medicine, University of PittsburghS10OD021533 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VERDELIS, KOSTAS · 2017 to 2017
$323k
NCRR NIH HHS S10 RR027383NIH HHS S10 OD021533
6 · The paper itself

Abstract

Acute coronary syndromes and strokes are mainly caused by atherosclerotic plaque (AP) rupture. Abnormal increase of vasa vasorum (VV) is reported as a key evidence of plaque progression and vulnerability. However, due to their tiny size, it is still challenging to noninvasively identify VV near the major vessels. Ultrasound super resolution (USR), a technique that provides high spatial resolution beyond the acoustic diffraction limit, demonstrated an adequate spatial resolution for VV detection in early studies. However, a thorough validation of this technology in the plaque model is particularly needed in order to continue further extended preclinical studies. In this letter, we present an experiment protocol that verifies the USR technology for VV identification with subsequent histology and ex vivo micro-computed tomography ( μ CT). Deconvolution-based USR imaging was applied on two rabbits to identify the VV near the AP in the femoral artery. Histology and ex vivo μ CT imaging were performed on excised femoral tissue to validate the USR technique both pathologically and morphologically. This established validation protocol could facilitate future extended preclinical studies toward the clinical translation of USR imaging for VV identification.

Indexed as

AlgorithmsAnimalsImage Processing, Computer-AssistedMalePlaque, AtheroscleroticRabbitsReproducibility of ResultsUltrasonographyVasa Vasorum

Identifiers

PMID32086204
PMCPMC7424774
OpenAlexW3007432462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.