Evidence map›Paper›PMID 32085996›Full record

ArticleEnvironmental research2020

Urinary cadmium and timing of menarche and pubertal development in girls.

Peggy Reynolds, Alison J Canchola, Christine N Duffy, Susan Hurley, Susan L Neuhausen, Pamela L Horn-Ross, Rudolph P Rull

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Invited Perspective: Metals and Menarche.Environmental health perspectives · 2023
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Peggy ReynoldsCancer Prevention Institute of California, Fremont, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. Electronic address: peggy.reynolds@ucsf.edu.
Alison J CancholaCancer Prevention Institute of California, Fremont, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Christine N DuffyCancer Prevention Institute of California, Fremont, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Susan HurleyCancer Prevention Institute of California, Fremont, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Pamela L Horn-RossCancer Prevention Institute of California, Fremont, CA, USA.
Rudolph P RullCancer Prevention Institute of California, Fremont, CA, USA; School of Community Health Sciences, University of Nevada, Reno, NV, USA.
Cancer Prevention Institute of California · USCity of Hope · USUniversity of California, San Francisco · USUniversity of Nevada, Reno · US

Funding

Center for Nutrient-Gene Interaction in Cancer PreventionU54CA100949 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARNES, STEPHEN · 2003 to 2008
$9.7M
NCI NIH HHS U54 CA100949
6 · The paper itself

Abstract

backgroundCadmium (Cd) is a developmental toxicant that is released into the environment during industrial processes. Previous animal studies suggest that Cd may impact the onset of puberty.

objectivesTo determine whether Cd exposure, measured as urinary Cd concentration, was associated with ages at menarche and pubertal development.

methodsA cohort of 211 girls, ages 10-13 years at baseline, was followed for up to two years. Girls completed an interview and self-assessment of Tanner stages of breast development and pubic hair growth. They were followed monthly until menarche. Urinary Cd concentrations were measured in overnight urine specimens. Multivariable Cox regression was used to evaluate the association between urinary Cd and age at menarche and cumulative logit regression was used to evaluate the associations between urinary Cd and breast development and pubic hair growth.

resultsThe baseline geometric mean creatinine-adjusted Cd concentration was 0.22 μg/g creatinine (geometric standard deviation = 1.6) and decreased with increasing age (p-trend = 0.04). Cd levels were higher among Asian than White girls or girls of other/mixed race/ethnicity (p = 0.04). In multivariable analyses, girls with urinary Cd ≥ 0.4 μg/L were less likely to have attained menarche than girls with urinary Cd < 0.2 μg/L (hazard ratio = 0.42; 95% confidence interval, 0.23-0.78). Urinary Cd was negatively associated with pubic hair growth (p-trend = 0.01) but not with breast development (p-trend = 0.72) at baseline.

conclusionsThese findings suggest that a higher Cd body burden may delay some aspects of pubertal development among girls.

Indexed as

Body BurdenCadmiumMenarchePubertyAdolescentChildCohort StudiesFemaleHumansSexual MaturationWhite PeopleCadmiumCadmiumMenarchePuberty

Identifiers

PMID32085996
PMCPMC8758186
OpenAlexW3004551377

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.