Evidence map›Paper›PMID 32085976›Full record

ReviewMolecular immunology2020

Non-coding RNAs in CD8 T cell biology.

Alexandria C Wells, Elena L Pobezinskaya, Leonid A Pobezinsky

Open access · greenAbstract readReview
In one paragraph

Review in Molecular immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Exploration (Beijing, China) · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. γδ T cells: origin and fate, subsets, diseases and immunotherapy.Signal transduction and targeted therapy · 2023
    Review
  7. Article
  8. Article
  9. Review
  10. MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Review
  12. Article
  13. Noncoding RNAs and Virus and Treatment in Allergic Rhinitis.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  14. Review
  15. Review
  16. Review
  17. microRNA dynamic expression regulates invariant NKT cells.Cellular and molecular life sciences : CMLS · 2021
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alexandria C WellsNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20814, United States. Electronic address: alex.wells@nih.gov.
Elena L PobezinskayaDepartment of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, 01003, United States. Electronic address: pobezinskaya@umass.edu.
Leonid A PobezinskyDepartment of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, 01003, United States. Electronic address: lpobezinsky@umass.edu.
University of Massachusetts Amherst · USNational Institutes of Health · US

Funding

Defining post-transcriptional mechanisms that control CD8 T cell longevity, proliferation and differentiationR01AI146188 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI POBEZINSKIY, LEONID · 2020 to 2024
$2.7M
Defining the role of let-7 miRNAs in the differentiation of exhausted and memory T cellsR21AI133041 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI POBEZINSKIY, LEONID · 2018 to 2019
$444k
NIAID NIH HHS R01 AI146188NIAID NIH HHS R21 AI133041
6 · The paper itself

Abstract

CD8 T cells are among the most vigorous soldiers of the immune system that fight viral infections and cancer. CD8 T cell development, maintenance, activation and differentiation are under the tight control of multiple transcriptional and post-transcriptional networks. Over the last two decades it has become clear that non-coding RNAs (ncRNAs), which consist of microRNAs (miRNAs) and long ncRNAs (lncRNAs), have emerged as global biological regulators. While our understanding of the function of specific miRNAs has increased since the discovery of RNA interference, it is still very limited, and the field of lncRNAs is just starting to blossom. Here we will summarize our knowledge on the role of ncRNAs in CD8 T cell biology, including differentiation into memory and exhausted cells.

Indexed as

AnimalsCD8-Positive T-LymphocytesCell DifferentiationGene Expression RegulationHumansImmunologic MemoryLymphocyte ActivationMiceMicroRNAsRNA InterferenceRNA, Long NoncodingRNA, UntranslatedMicroRNAsRNA, Long NoncodingRNA, UntranslatedCTLEffectorExhaustionlncRNAMemorymiRNANaïve

Identifiers

PMID32085976
PMCPMC7093237
OpenAlexW3007265272

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.