Evidence map›Paper›PMID 32085921›Full record

ReviewBiological psychiatry. Cognitive neuroscience and neuroimaging2020

Data-Driven Diagnostics and the Potential of Mobile Artificial Intelligence for Digital Therapeutic Phenotyping in Computational Psychiatry.

Peter Washington, Natalie Park, Parishkrita Srivastava, Catalin Voss, Aaron Kline, Maya Varma, Qandeel Tariq, Haik Kalantarian, Jessey Schwartz, Ritik Patnaik and 5 more

Abstract readReview
In one paragraph

Review in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Sex-Based Differences in Prenatal and Perinatal Predictors of Autism Spectrum Disorder Using Machine Learning With National Health Data.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Challenges in the Differential Classification of Individual Diagnoses from Co-Occurring Autism and ADHD Using Survey Data.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2024
    Article
  12. Article
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  15. Article
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  19. Article
  20. Digital therapeutics in the clinic.Bioengineering & translational medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Peter WashingtonDepartment of Bioengineering, Stanford University, Stanford, California.
Natalie ParkDepartment of Biological Sciences, Columbia University, New York, New York.
Parishkrita SrivastavaDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California.
Catalin VossDepartment of Computer Science, Stanford University, Stanford, California.
Aaron KlineDepartment of Pediatrics (Systems Medicine), Stanford University, Stanford, California; Department of Biomedical Data Science, Stanford University, Stanford, California.
Maya VarmaDepartment of Computer Science, Stanford University, Stanford, California.
Qandeel TariqDepartment of Pediatrics (Systems Medicine), Stanford University, Stanford, California; Department of Biomedical Data Science, Stanford University, Stanford, California.
Haik KalantarianDepartment of Pediatrics (Systems Medicine), Stanford University, Stanford, California; Department of Biomedical Data Science, Stanford University, Stanford, California.
Jessey SchwartzDepartment of Pediatrics (Systems Medicine), Stanford University, Stanford, California; Department of Biomedical Data Science, Stanford University, Stanford, California.
Ritik PatnaikDepartment of Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Brianna ChrismanDepartment of Bioengineering, Stanford University, Stanford, California.
Nathaniel StockhamDepartment of Neuroscience, Stanford University, Stanford, California.
Kelley PaskovDepartment of Biomedical Data Science, Stanford University, Stanford, California.
Nick HaberSchool of Education, Stanford University, Stanford, California.
Dennis P WallDepartment of Pediatrics (Systems Medicine), Stanford University, Stanford, California; Department of Biomedical Data Science, Stanford University, Stanford, California; Department of Psychiatry and Behavioral Sciences (by courtesy), Stanford University, Stanford, California. Electronic address: dpwall@stanford.edu.

Funding

POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Characterizing the genetic systems of autism through multi-disease analysisR01MH090611 · NIMH · STANFORD UNIVERSITY · PI WALL, DENNIS PAUL · 2010 to 2014
$2.8M
Creating an artificial intelligence therapy-to-data feedback loop for child developmental healthcareR01LM013083 · NLM · STANFORD UNIVERSITY · PI WALL, DENNIS PAUL · 2019 to 2022
$2.6M
Biomedical Data Science Graduate Training at StanfordT32LM012409 · NLM · STANFORD UNIVERSITY · PI PLEVRITIS, SYLVIA KATINA · 2016 to 2020
$1.5M
QuBBD: Wearable artificial intelligence for bid data-driven healthcare in child development R01EB025025 · NIBIB · STANFORD UNIVERSITY · PI WALL, DENNIS PAUL · 2017 to 2019
$1.1M
Evaluation of machine learning to mobilize detection and therapy of developmental delay in childrenR21HD091500 · NICHD · STANFORD UNIVERSITY · PI WALL, DENNIS PAUL · 2017 to 2018
$432k
NIBIB NIH HHS R01 EB025025NICHD NIH HHS R21 HD091500NIMH NIH HHS R01 MH090611NLM NIH HHS R01 LM013083NLM NIH HHS T15 LM007033NLM NIH HHS T32 LM012409
6 · The paper itself

Abstract

Data science and digital technologies have the potential to transform diagnostic classification. Digital technologies enable the collection of big data, and advances in machine learning and artificial intelligence enable scalable, rapid, and automated classification of medical conditions. In this review, we summarize and categorize various data-driven methods for diagnostic classification. In particular, we focus on autism as an example of a challenging disorder due to its highly heterogeneous nature. We begin by describing the frontier of data science methods for the neuropsychiatry of autism. We discuss early signs of autism as defined by existing pen-and-paper-based diagnostic instruments and describe data-driven feature selection techniques for determining the behaviors that are most salient for distinguishing children with autism from neurologically typical children. We then describe data-driven detection techniques, particularly computer vision and eye tracking, that provide a means of quantifying behavioral differences between cases and controls. We also describe methods of preserving the privacy of collected videos and prior efforts of incorporating humans in the diagnostic loop. Finally, we summarize existing digital therapeutic interventions that allow for data capture and longitudinal outcome tracking as the diagnosis moves along a positive trajectory. Digital phenotyping of autism is paving the way for quantitative psychiatry more broadly and will set the stage for more scalable, accessible, and precise diagnostic techniques in the field.

Indexed as

Autistic DisorderPsychiatryArtificial IntelligenceChildHumansMachine LearningArtificial intelligenceAutismContinuous phenotypingDigital therapeuticsMachine learningMobile diagnostics

Identifiers

PMID32085921
PMCPMC7292741

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.