Evidence map›Paper›PMID 32085793›Full record

ArticleTrials2020

Mesenteric excision surgery or conservative limited resection in Crohn's disease: study protocol for an international, multicenter, randomized controlled trial.

Yi Li, Helen Mohan, Nan Lan, Xiaojian Wu, Wei Zhou, Jianfeng Gong, Bo Shen, Luca Stocchi, J Calvin Coffey, Weiming Zhu

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03769922 (The MESOCOLIC Trial), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03769922 naunknown statusnot on this map

The MESOCOLIC Trial: Mesenteric Excision Surgery or Conservative Limited Resection in Crohn's Disease

TypeinterventionalSponsorJinling Hospital, ChinaRan2019 to 2025Enrolled116ConditionsPostoperative Surgical RecurrenceArmsExtensive mesenteric resection, Limited mesenteric excision
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Article
  7. The Surgical Management of the Mesentery in Crohn's Disease.Clinics in colon and rectal surgery · 2025
    Review
  8. Bowel Resection Margins in Crohn's Disease: Do They Matter?Clinics in colon and rectal surgery · 2025
    Review
  9. Review
  10. Article
  11. The Mesentery's Pivotal Role in the Brain-Gut-Liver Axis.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2024
    Article
  12. Review
  13. Article
  14. Perioperative optimization of Crohn's disease.Annals of gastroenterological surgery · 2023
    Review
  15. Article
  16. Review
  17. Intriguing Role of the Mesentery in Ileocolic Crohn's Disease.Clinics in colon and rectal surgery · 2022
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Yi LiCenter for Inflammatory Bowel Diseases, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Helen MohanDepartment of Surgery, Surgical Professorial Unit, University Hospital Limerick, Limerick, Ireland.
Nan LanDepartment of Colorectal Surgery, Digestive Disease and Surgery Institute Cleveland Clinic, 9500 Euclid Avenue, A30, Cleveland, OH, 44195-0001, USA.
Xiaojian WuDepartment of Colorectal Surgery, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Wei ZhouDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou, China.
Jianfeng GongCenter for Inflammatory Bowel Diseases, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Bo ShenSection of Inflammatory Bowel Diseases and Center for Interventional IBD, Columbia University Irving Medical Center-NewYork Presbyterian, New York, NY, USA.
Luca StocchiDepartment of Colorectal Surgery, Digestive Disease and Surgery Institute Cleveland Clinic, 9500 Euclid Avenue, A30, Cleveland, OH, 44195-0001, USA. stocchl@ccf.org.
J Calvin CoffeyDepartment of Surgery, Surgical Professorial Unit, University Hospital Limerick, Limerick, Ireland. calvin.coffey@ul.ie.
Weiming ZhuCenter for Inflammatory Bowel Diseases, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. juwiming@nju.edu.cn.
Cleveland Clinic · USNanjing University · CNUniversity Hospital Limerick · IEColumbia University Irving Medical Center · USNanjing General Hospital of Nanjing Military Command · CNSun Yat-sen University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe structures of the mesentery including adipose tissue, nerves, and lymphatics play an important role in the pathogenesis and disease progression of Crohn's disease (CD). Conventional surgical resection for CD usually does not involve resecting the mesentery en bloc with the specimen. This contrasts with complete mesocolic excision (CME) in colorectal cancer, which involves radical resection of the mesentery. Preliminary evidence from smaller studies suggests that applying the principle of mesocolic excision to CD surgery may reduce the risk of postoperative recurrence. This randomized controlled trial is designed to test whether applying the principles of mesocolic excision to CD results in reduced postoperative recurrence. It also aims to evaluate intra- and postoperative morbidity between the two approaches.

methodsThis international, multicenter, randomized controlled trial will randomize patients (n = 116) scheduled to undergo primary ileocolic resection to either receive extensive mesenteric excision (EME) or conventional ileocolic resection with limited mesenteric excision (LME). Five sites will recruit patients in three countries. In the EME group, the mesentery is resected following CME, while avoiding the root region, i.e., 1 cm from the root of the ileocolic artery and vein. In the LME group, the mesentery is retained, i.e., "close shave" or < 3 cm from the border of bowel. The primary end point will be surgical recurrence after surgery. The secondary end points will be the postoperative endoscopic and clinical recurrence, and intra- and postoperative morbidity. Demographics, risk factors, laboratory investigations, endoscopy, postoperative prophylaxis and imaging examination will be assessed. Analysis of the primary outcome will be on an intention-to-treat basis. DISCUSSION: If mesocolic excision in CD reduces postoperative disease recurrence and does not increase morbidity, this trial has the potential to change practice and reduce recurrence of CD after surgical resection.

trial registrationClinical Trials.gov, ID: NCT03769922. Registered on February 27, 2019.

Indexed as

ColectomyColonCrohn DiseaseDisease ProgressionDissectionHumansIleumInternationalityLymph Node ExcisionMesenteryMulticenter Studies as TopicOutcome and Process Assessment, Health CareRandomized Controlled Trials as TopicRecurrenceRisk FactorsCrohn’s diseaseIleocolic resectionMesenteryPostoperative recurrence

Identifiers

PMID32085793
PMCPMC7035646
OpenAlexW3012657071

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.