Evidence map›Paper›PMID 32085738›Full record

ArticleBMC cancer2020

Trajectories of physical activity, from young adulthood to older adulthood, and pancreatic cancer risk; a population-based case-control study in Ontario, Canada.

Jaspreet Sandhu, Vanessa De Rubeis, Michelle Cotterchio, Brendan T Smith, Lauren E Griffith, Darren R Brenner, Ayelet Borgida, Steven Gallinger, Sean Cleary, Laura N Anderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Trajectory of physical activity frequency and cancer risk: Findings from a population-based cohort study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jaspreet SandhuDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Vanessa De RubeisDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Michelle CotterchioPrevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada.
Brendan T SmithDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Lauren E GriffithDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Darren R BrennerAlberta Health Services, Cancer Control, Calgary, AB, Canada.
Ayelet BorgidaLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Steven GallingerLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Sean ClearyDepartment of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.
Laura N AndersonDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. ln.anderson@mcmaster.ca.ORCID http://orcid.org/0000-0002-6106-5073

Funding

Pancreatic Cancer Genetic Epidemiology Consortium (PACGENE)R01CA097075 · NCI · MAYO CLINIC ROCHESTER · PI PETERSEN, GLORIA M. · 2002 to 2012
$15.8M
Canadian Institutes of Health Research (CA) AO2-151560Canadian Institutes of Health Research (CA) MOP-106631National Institutes of Health (US) RO1 CA97075NCI NIH HHS R01 CA097075
6 · The paper itself

Abstract

backgroundThere is inconsistent evidence on the association between physical activity and pancreatic cancer risk and few studies have investigated early life or life-course physical activity. The objective of this study was to evaluate the association between trajectories of physical activity across the life-course and pancreatic cancer risk.

methodsA population-based case-control study was conducted (2011-2013) using cases (n = 315) from the Ontario Pancreas Cancer Study and controls (n = 1254) from the Ontario Cancer Risk Factor Study. Self-reported recall of moderate and vigorous physical activity was measured at three time points: young adulthood (20s-30s), mid-adulthood (40s-50s) and older-adulthood (1 year prior to questionnaire completion). Physical activity trajectories were identified using latent class analysis. Odds ratios (OR) and 95% confidence intervals (CI) were estimated from multivariable logistic regression adjusted for covariates: age, sex, race, alcohol, smoking, vegetable, fruit and meat consumption, and family history of pancreatic cancer.

resultsSix life-course physical activity trajectories were identified: inactive at all ages (41.2%), low activity at all ages (31.9%), increasingly active (3.6%), high activity in young adulthood with substantial decrease (13.0%), high activity in young adulthood with slight decrease (5.0%), and persistent high activity (5.3%). Compared to the inactive at all ages trajectory, the associations between each trajectory and pancreatic cancer after confounder adjustment were: low activity at all ages (OR: 1.11; 95% CI: 0.75, 1.66), increasingly active (OR: 1.11; 95% CI: 0.56, 2.21), high activity in young adulthood with substantial decrease in older adulthood (OR: 0.76; 95% CI: 0.47, 1.23), high activity in young adulthood with slight decrease in older adulthood (OR: 0.98; 95% CI: 0.62, 1.53), and persistently high activity (OR: 1.50; 95% CI: 0.86, 2.62). When time periods were evaluated separately, the OR for the association between high moderate activity in the 20s-30s and pancreatic cancer was 0.89 (95% CI: 0.64, 1.25) and some sex differences were observed.

conclusionDistinct life-course physical activity trajectories were identified, but there was no evidence that any of the trajectories were associated with pancreatic cancer. Future studies with larger sample sizes are needed to understand the associations between physical activity trajectories over the life-course and pancreatic cancer risk.

Indexed as

ExerciseAgedAge FactorsCase-Control StudiesFemaleHumansIncidenceMaleMiddle AgedOntarioPancreatic NeoplasmsRisk FactorsSelf ReportSurveys and QuestionnairesLife-coursePancreatic cancerPhysical activityTrajectory

Identifiers

PMID32085738
PMCPMC7035748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.