ArticleJournal of clinical medicine2020
Neutrophil-Lymphocyte Ratio in Patients with Acute Heart Failure Predicts In-Hospital and Long-Term Mortality.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 5 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Association of inflammatory markers with clinical outcomes in atrial fibrillation: a meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Association between haemoglobin, albumin, lymphocytes, and platelets and mortality in patients with heart failure.ESC heart failure · 2024Pooled it
- The association between hematological markers of inflammation and chronic cannabis use: a systematic review and meta-analysis of observational studies.Frontiers in psychiatry · 2024Pooled it
- Neutrophil to lymphocyte ratio (NLR) prognostic effects on heart failure; a systematic review and meta-analysis.BMC cardiovascular disorders · 2023Pooled it
- Prognostic role of neutrophil-to-lymphocyte ratio in aortic disease: a meta-analysis of observational studies.Journal of cardiothoracic surgery · 2020Pooled it
- Myeloperoxidase inhibition with mitiperstat in heart failure with preserved or mildly reduced ejection fraction: a randomized phase 2b trial.Nature medicine · 2026Trial
- Baseline neutrophil-to-lymphocyte ratio and efficacy of SGLT2 inhibition with empagliflozin on cardiac remodelling.ESC heart failure · 2023Trial
- Prognostic value of C-reactive protein-triglyceride-glucose index in hospitalised patients with acute decompensated heart failure.BMC cardiovascular disorders · 2026Article
- White blood cells and neutrophil-to-high density lipoprotein ratio as predictive markers of left ventricular dysfunction in heart failure.World journal of methodology · 2026Article
- Discharge neutrophily-to-lymphocyte ratio and its trajectory as predictors of 30-day outcomes in acute heart failure.ESC heart failure · 2026Article
- Establishment and Validation of Nomogram Model Based on Neutrophil Lymphocyte Ratio for Prognosis of Patients With Congestive Heart Failure.Cardiology research and practice · 2026Article
- Prognostic Value of Systemic Inflammatory Indices in Hospitalized Patients with HFrEF: A Multicenter Retrospective Cohort Study.International journal of general medicine · 2026Article
- Prognostic markers in pediatric dilated cardiomyopathy: Focus on the neutrophil-to-lymphocyte ratio and the systemic inflammatory index.Experimental and therapeutic medicine · 2025Article
- The importance of Naples prognostic score in predicting long-term mortality in heart failure patients.Annals of medicine · 2025Article
- Statistical Study for the Prognostic Value of NLR Values in Patients with Severe Burns: A Study in the Service of Burns in Albania.Annals of burns and fire disasters · 2025Article
- HearteXplain: explainable prediction of acute heart failure and identification of hematologic biomarkers using EBMs and Morris sensitivity analysis.Scientific reports · 2025Article
- Neutrophil-to-Lymphocyte Ratio, Bone Marrow, and Visceral Fat Metabolism as Predictors of Future Cardiovascular Disease in an Asymptomatic Healthy Population.Journal of clinical medicine · 2025Article
- Article
- Silent Inflammation, Loud Consequences: Decoding NLR Across Renal, Cardiovascular and Metabolic Disorders.International journal of molecular sciences · 2025Review
- Prognostic impact of systemic immune inflammatory index in patients with reduced ejection fraction heart failure.BMC cardiovascular disorders · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 11 institutions in 1 country.
Funding
Abstract
The application of a simple blood test to predict prognosis in acute heart failure (AHF) patients is not well established. Neutrophil-lymphocyte ratio (NLR) is inexpensive and easy to obtain in hospitalized patients using a routine blood test. We evaluate the prognostic implications of NLR as an independent predictor of in-hospital and long-term mortality in AHF patients. Among 5625 patients enrolled in the Korean Acute Heart Failure registry, 5580 patients were classified into quartiles by their NLR level, and analyzed for in-hospital and post-discharge three-year mortality. Patients in the highest NLR quartile had the highest in-hospital and post-discharge three-year mortality. The same results were seen by dividing the aggravating factor into the infection or ischemia group and the non-infection or non-ischemia group. For patients aggravated from infection or ischemia, a cut-off NLR value was 7.0 that increase the risk of in-hospital and post-discharge three-year mortality. In subgroups of patients not aggravated from infection or ischemia, a cut-off NLR value was 5.0 that increase the risk of in-hospital and post discharge three-year mortality. Elevated NLR in AHF patients at the index hospitalization is an independent predictor for in-hospital and post-discharge three-year mortality. Taken together, NLR is a marker for risk assessment of AHF patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.