ArticleAntibiotics (Basel, Switzerland)2020
Metal Complexes, an Untapped Source of Antibiotic Potential?
Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 189 citations in OpenAlex.
- Antibiotic-Free Strategies for Managing Antimicrobial-Resistant Infections.Pharmaceutics · 2026Review
- Broad-Spectrum Antimicrobial Activity of a Ruthenium(II) Polypyridyl Complex against Multidrug-Resistant Uropathogens and Biofilms.ACS omega · 2026Article
- Iron(III)-Tropolone Complex as a Topical Agent Against Drug-Resistant MRSA Skin Infections.Antibiotics (Basel, Switzerland) · 2026Article
- Fluorinated Rh(I)-NHC Compounds as Potential Antibacterials Against Multidrug-ResistantPharmaceutics · 2025Article
- Mechanisms Operating in the Use of Transition Metal Complexes to Combat Antimicrobial Resistance.Microorganisms · 2025Review
- Metal compounds as antimicrobial agents: 'smart' approaches for discovering new effective treatments.RSC advances · 2025Review
- In Vitro and In Vivo Studies on a Mononuclear Ruthenium Complex Reveals It is a Highly Effective, Fast-Acting, Broad-Spectrum Antimicrobial in Physiologically Relevant Conditions.ACS infectious diseases · 2024Article
- Sorbate metal complexes as newer antibacterial, antibiofilm, and anticancer compounds.BMC microbiology · 2024Article
- Structural Design, Anticancer Evaluation, and Molecular Docking of Newly Synthesized Ni(II) Complexes withMolecules (Basel, Switzerland) · 2024Article
- The good, the bad, and the ugly of metals as antimicrobials.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- Silver Complexes of Miconazole and Metronidazole: Potential Candidates for Melanoma Treatment.International journal of molecular sciences · 2024Article
- Supercharged precision killers: Genetically engineered biomimetic drugs of screened metalloantibiotics againstScience advances · 2024Article
- Discovery of antibacterial manganese(i) tricarbonyl complexes through combinatorial chemistry.Chemical science · 2024Article
- Impact of mucus and biofilm on antimicrobial photodynamic therapy: Evaluation using Ruthenium(II) complexes.Biofilm · 2023Article
- Silver, Its Salts and Application in Medicine and Pharmacy.International journal of molecular sciences · 2023Review
- Structures, Antioxidant Properties, and Antimicrobial Properties of Eu(III), Gd(III), and Dy(III) Caffeinates andMolecules (Basel, Switzerland) · 2023Article
- The Lung Microbiome in COPD and Lung Cancer: Exploring the Potential of Metal-Based Drugs.International journal of molecular sciences · 2023Review
- New Palladium(II) Complexes Containing Methyl Gallate and Octyl Gallate: Effect againstMolecules (Basel, Switzerland) · 2023Article
- Computer-Aided Drug Design and Synthesis of Rhenium Clotrimazole Antimicrobial Agents.Antibiotics (Basel, Switzerland) · 2023Article
- Synthesis, antioxidant activity, antimicrobial efficacy and molecular docking studies of 4-chloro-2-(1-(4-methoxyphenyl)-4,5-diphenyl-1RSC advances · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
With the widespread rise of antimicrobial resistance, most traditional sources for new drug compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal complexes have long had only a niche presence in the medicinal chemistry landscape, despite some compounds, such as the anticancer drug cisplatin, having had a profound impact and still being used extensively in cancer treatments today. Indeed, metal complexes have been largely ignored for antibiotic development. This is surprising as metal compounds have access to unique modes of action and exist in a wider range of three-dimensional geometries than purely organic compounds. These properties make them interesting starting points for the development of new drugs. In this perspective article, , the encouraging work that has been done on antimicrobial metal complexes, mainly over the last decade, is highlighted. Promising metal complexes, their activity profiles, and possible modes of action are discussed and issues that remain to be addressed are emphasized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.