ReviewNutrients2020
Nutrition in Necrotizing Enterocolitis and Following Intestinal Resection.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Nutritional management of neonates who undergo major surgery for gastrointestinal disorders: a joint position paper of the Italian Society of Neonatology (SIN), the Italian Society of Pediatric Surgery (SICP), and the Italian Society of Pediatric Nutrition (SINUPE).Italian journal of pediatrics · 2026Guideline
- Quality improvement interventions to prevent neonatal necrotizing enterocolitis: a systematic review.Frontiers in pediatrics · 2025Pooled it
- Updates in the Management of Short Bowel Syndrome Secondary to Intestinal Resection in the Pediatric Population.Journal of clinical medicine · 2026Review
- Nutritional management after necrotizing enterocolitis and focal intestinal perforation in preterm infants.Pediatric research · 2026Review
- Micronutrient Deficiencies in Infants Following Gastrointinal Surgery at the National Children's Hospital.Pediatric gastroenterology, hepatology & nutrition · 2026Article
- Effect of Dietary Capsaicinoids Supplementation on Growth Performance, Intestinal Morphology, and Colon Microbiota in Weaned Piglets.Antioxidants (Basel, Switzerland) · 2026Article
- Therapeutic potential and translational challenges of extracellular vesicles in neonatal medicine.Bioengineering & translational medicine · 2026Review
- Enteral Feeding With Omega-3 Polyunsaturated Fatty Acids Mitigates Liver Injury Following Massive Intestinal Resection.Cellular and molecular gastroenterology and hepatology · 2026Article
- Rate of postoperative weight gain and clinical outcomes in patients undergoing surgery for necrotizing enterocolitis.Translational pediatrics · 2025Article
- An early post-birth immune-microbiota landscape predicts the development of necrotizing enterocolitis in term newborns with congenital heart defects.Scientific reports · 2025Article
- Association of timing of initial breastfeeding and neonatal outcome in very preterm infants: a multicentre cohort study in China.BMJ paediatrics open · 2025Observational
- Human breast milk-derived exosomes and their positive role on neonatal intestinal health.Pediatric research · 2025Review
- A Nomogram for Predicting Surgical Risk in Neonates with Necrotizing Enterocolitis: A Retrospective Cohort Study.Indian journal of pediatrics · 2025Article
- Review
- Quantitative Proteomic Analysis Identifying and Evaluating TRAF6 and IL-8 as Potential Diagnostic Biomarkers in Neonatal Patients with Necrotizing Enterocolitis.Molecular biotechnology · 2025Article
- Optimizing nutritional strategies in term NEC and perforation infants after intestinal operation: a retrospective study.Scientific reports · 2025Article
- Clinical Characteristics and Influencing Factors of Feeding Intolerance After Surgery for Neonatal Necrotizing Enterocolitis.Children (Basel, Switzerland) · 2025Article
- M2-type macrophage nanovesicles regulate the inflammatory response after necrotizing enterocolitis by inducing M1 to M2-like macrophage polarization.Frontiers in cellular and infection microbiology · 2025Article
- The influence of the maternal microbiome on offspring neurodevelopment: a critical review of associations, controversies, and challenges.Frontiers in neuroscience · 2025Review
- Analysis of Postoperative Outcomes and Extrauterine Growth Retardation in Preterm Infants with Necrotizing Enterocolitis: A Retrospective Study.American journal of perinatology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review aims to discuss the role of nutrition and feeding practices in necrotizing enterocolitis (NEC), NEC prevention, and its complications, including surgical treatment. A thorough PubMed search was performed with a focus on meta-analyses and randomized controlled trials when available. There are several variables in nutrition and the feeding of preterm infants with the intention of preventing necrotizing enterocolitis (NEC). Starting feeds later rather than earlier, advancing feeds slowly and continuous feeds have not been shown to prevent NEC and breast milk remains the only effective prevention strategy. The lack of medical treatment options for NEC often leads to disease progression requiring surgical resection. Following resection, intestinal adaptation occurs, during which villi lengthen and crypts deepen to increase the functional capacity of remaining bowel. The effect of macronutrients on intestinal adaptation has been extensively studied in animal models. Clinically, the length and portion of intestine that is resected may lead to patients requiring parenteral nutrition, which is also reviewed here. There remain significant gaps in knowledge surrounding many of the nutritional aspects of NEC and more research is needed to determine optimal feeding approaches to prevent NEC, particularly in infants younger than 28 weeks and <1000 grams. Additional research is also needed to identify biomarkers reflecting intestinal recovery following NEC diagnosis individualize when feedings should be safely resumed for each patient.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.