Evidence map›Paper›PMID 32085585›Full record

ArticleCells2020

The Vacuolar H

Mette Flinck, Sofie Hagelund, Andrej Gorbatenko, Marc Severin, Elena Pedraz-Cuesta, Ivana Novak, Christian Stock, Stine Falsig Pedersen

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Displacement of Native FXYD Protein From NaFrontiers in oncology · 2022
    Article
  7. Review
  8. The V-ATPaseInternational journal of molecular sciences · 2021
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Mette FlinckSection for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Sofie HagelundSection for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Andrej GorbatenkoDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Marc SeverinSection for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Elena Pedraz-CuestaSection for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Ivana NovakSection for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Christian StockDepartment of Gastroentero-, Hepato- and Endocrinology, Hannover Medical School, D-30625 Hannover, Germany.
Stine Falsig PedersenSection for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark.
University of Copenhagen · DKIcahn School of Medicine at Mount Sinai · USMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased metabolic acid production and upregulation of net acid extrusion render pH homeostasis profoundly dysregulated in many cancers. Plasma membrane activity of vacuolar H

Indexed as

AutophagyCarcinoma, Pancreatic DuctalCell Line, TumorCell MovementCell ProliferationGene Knockdown TechniquesHumansHydrogen-Ion ConcentrationHypoxia-Inducible Factor 1, alpha SubunitNeoplasm InvasivenessPancreatic NeoplasmsProtease InhibitorsProtein SubunitsSignal TransductionUp-RegulationVacuolar Proton-Translocating ATPasesHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitProtease InhibitorsProtein SubunitsTCIRG1 protein, humanVacuolar Proton-Translocating ATPasesATP6V0a3autophagyinvasionmatrix degradationmigrationPDACpH-regulationproliferationTCIRG1

Identifiers

PMID32085585
PMCPMC7072798
OpenAlexW3009006264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.