Evidence map›Paper›PMID 32085421›Full record

ArticleBiomolecules2020

Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast.

Leticia Pollo-Oliveira, Roland Klassen, Nick Davis, Akif Ciftci, Jo Marie Bacusmo, Maria Martinelli, Michael S DeMott, Thomas J Begley, Peter C Dedon, Raffael Schaffrath and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Review
  6. Article
  7. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  8. Review
  9. Role ofInternational journal of molecular sciences · 2021
    Article
  10. Review
  11. Review
  12. Article
  13. Article
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  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Leticia Pollo-OliveiraDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL 32603, USA.
Roland KlassenInstitut für Biologie, Fachgebiet Mikrobiologie, Universität Kassel, 34132 Kassel, Germany.ORCID 0000-0002-0809-0050
Nick DavisDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Akif CiftciInstitut für Biologie, Fachgebiet Mikrobiologie, Universität Kassel, 34132 Kassel, Germany.
Jo Marie BacusmoDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL 32603, USA.
Maria MartinelliDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL 32603, USA.
Michael S DeMottDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Thomas J BegleyThe RNA Institute, College of Arts and Science, University at Albany, SUNY, Albany, NY 12222, USA.
Peter C DedonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-0011-3067
Raffael SchaffrathInstitut für Biologie, Fachgebiet Mikrobiologie, Universität Kassel, 34132 Kassel, Germany.ORCID 0000-0001-9484-5247
Valérie de Crécy-LagardDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL 32603, USA.ORCID 0000-0002-9955-3785
University of Florida · USMassachusetts Institute of Technology · USUniversity of Kassel · DEUniversity at Albany, State University of New York · US

Funding

Synthesis and function of Queuosine in BacteriaR01GM070641 · NIGMS · UNIVERSITY OF FLORIDA · PI DE CRECY-LAGARD, VALERIE A · 2006 to 2023
$5.3M
Deutsche Forschungsgemeinschaft SCHA750/15Deutsche Forschungsgemeinschaft SCHA750/18Deutsche Forschungsgemeinschaft SCHA750/20NIGMS NIH HHS R01 GM070641NIH HHS ES002109
6 · The paper itself

Abstract

Modifications found in the Anticodon Stem Loop (ASL) of tRNAs play important roles in regulating translational speed and accuracy. Threonylcarbamoyl adenosine (t

Indexed as

AnticodonDNA-Binding ProteinsHistone AcetyltransferasesNucleic Acid ConformationPhenotypeProtein AggregatesProtein BiosynthesisProteinsProteomicsRNA, TransferSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsThermodynamicsThiouridine5-carbomethoxymethyl-2-thiouridineAnticodonDNA-Binding ProteinsElp3 protein, S cerevisiaeHistone AcetyltransferasesProtein AggregatesProteinsRNA, TransferSaccharomyces cerevisiae ProteinsSUA5 protein, S cerevisiaeThiouridineprotein aggregationtRNA modification

Identifiers

PMID32085421
PMCPMC7072221
OpenAlexW2999581093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.