ArticlePlants (Basel, Switzerland)2020
Mitochondrial DNA Repair in an
Article in Plants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Multiple inducible DNA double-strand breaks using a restriction endonuclease in Arabidopsis thaliana mitochondria.BMC plant biology · 2026Article
- Uracil-DNA Glycosylase fromInternational journal of molecular sciences · 2025Article
- Mapping-based genome size estimation.BMC genomics · 2025Article
- Base Excision DNA Repair in Plants:International journal of molecular sciences · 2023Review
- Long-read sequencing characterizes mitochondrial and plastid genome variants in Arabidopsis msh1 mutants.The Plant journal : for cell and molecular biology · 2022Article
- Article
- Detecting de novo mitochondrial mutations in angiosperms with highly divergent evolutionary rates.Genetics · 2021Article
- Plant Mitochondria are a Riddle Wrapped in a Mystery Inside an Enigma.Journal of molecular evolution · 2021Article
- Interplay Among Hydrogen Sulfide, Nitric Oxide, Reactive Oxygen Species, and Mitochondrial DNA Oxidative Damage.Frontiers in plant science · 2021Review
- Article
- Plant Organelle DNA Maintenance.Plants (Basel, Switzerland) · 2020Article
- The Tempo and Mode of Angiosperm Mitochondrial Genome Divergence Inferred from Intraspecific Variation inG3 (Bethesda, Md.) · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Substitution rates in plant mitochondrial genes are extremely low, indicating strong selective pressure as well as efficient repair. Plant mitochondria possess base excision repair pathways; however, many repair pathways such as nucleotide excision repair and mismatch repair appear to be absent. In the absence of these pathways, many DNA lesions must be repaired by a different mechanism. To test the hypothesis that double-strand break repair (DSBR) is that mechanism, we maintained independent self-crossing lineages of plants deficient in uracil-N-glycosylase (UNG) for 11 generations to determine the repair outcomes when that pathway is missing. Surprisingly, no single nucleotide polymorphisms (SNPs) were fixed in any line in generation 11. The pattern of heteroplasmic SNPs was also unaltered through 11 generations. When the rate of cytosine deamination was increased by mitochondrial expression of the cytosine deaminase APOBEC3G, there was an increase in heteroplasmic SNPs but only in mature leaves. Clearly, DNA maintenance in reproductive meristem mitochondria is very effective in the absence of UNG while mitochondrial genomes in differentiated tissue are maintained through a different mechanism or not at all. Several genes involved in DSBR are upregulated in the absence of UNG, indicating that double-strand break repair is a general system of repair in plant mitochondria. It is important to note that the developmental stage of tissues is critically important for these types of experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.