ReviewPathogens (Basel, Switzerland)2020
Host Factors Affecting Generation of Immunity Against Porcine Epidemic Diarrhea Virus in Pregnant and Lactating Swine and Passive Protection of Neonates.
Review in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Systematic review of animal-based indicators to measure thermal, social, and immune-related stress in pigs.PloS one · 2022Pooled it
- Magnolol inhibits porcine epidemic diarrhea virus infection by suppressing cathepsin L expressionJournal of virology · 2026Article
- Overcoming Antigenic Drift in PEDV: Broadly Protective Antigen Design and sIgA-Driven Lactogenic Immunity.Veterinary sciences · 2026Review
- Prescribed RNA Particle Vaccine Against Porcine Sapovirus Enhances Virus-Neutralizing Antibody Titers in Colostrum and Milk.Pathogens (Basel, Switzerland) · 2026Article
- PEDV regulates trans-mammary epithelial migration of T cells in a CCR10/CCL28-dependent manner.Journal of virology · 2026Article
- Investigating habitat preferences and host-feeding behavior of mosquito disease vectors on commercial swine farms in the USA.Parasites & vectors · 2026Article
- Isolation, genomic characterization, and pathogenicity of an emerging PEDV variant in Korea related to virulent Chinese strains.Frontiers in veterinary science · 2026Article
- Prevention of Porcine Epidemic Diarrhea Virus With Nanotube-Adjuvanted Oral DNA Vaccines.Transboundary and emerging diseases · 2026Article
- First molecular detection of porcine rotavirus B (RVB) in Poland - case study and genome analysis.Porcine health management · 2025Article
- Identification of PEDV inhibitors targeting 3CL protease.Virologica Sinica · 2025Article
- Engineering a recombination-resistant live attenuated vaccine candidate with suppressed interferon antagonists for PEDV.Journal of virology · 2025Article
- Ferritin-based nanoparticle vaccine protects neonatal piglets against porcine epidemic diarrhea virus challenge following immunization of pregnant sows.Veterinary research · 2025Article
- Genetic characterization and pathogenicity analysis of three porcine epidemic diarrhea virus strains isolated from North China.Veterinary research · 2025Article
- Editorial: Mucosal immunity after vaccination.Frontiers in immunology · 2025Article
- Microbiome analysis reveals gut bacterial alterations in adult Tibetan pigs with diarrhea.Frontiers in microbiology · 2025Article
- Efficacy evaluation of a bivalent subunit vaccine against epidemic PEDV heterologous strains with low cross-protection.Journal of virology · 2024Article
- Serum IgA antibody level against porcine epidemic diarrhea virus is a potential pre-evaluation indicator of immunization effects in sows during parturition under field conditions.Porcine health management · 2024Article
- Bioactive Components of Human Milk and Their Impact on Child's Health and Development, Literature Review.Nutrients · 2024Review
- Porcine Epidemic Diarrhea Virus: Etiology, Epidemiology, Antigenicity, and Control Strategies in China.Animals : an open access journal from MDPI · 2024Review
- Research progress of porcine epidemic diarrhea virus S protein.Frontiers in microbiology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Porcine epidemic diarrhea virus (PEDV) is a highly virulent re-emerging enteric coronavirus that causes acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets. Despite this, a safe and effective PEDV vaccine against highly virulent strains is unavailable, making PEDV prevention and control challenging. Lactogenic immunity induced via the gut-mammary gland-secretory IgA (sIgA) axis, remains the most promising and effective way to protect suckling piglets from PEDV. Therefore, a successful PEDV vaccine must induce protective maternal IgA antibodies that passively transfer into colostrum and milk. Identifying variables that influence lymphocyte migration and IgA secretion during gestation and lactation is imperative for designing maternal immunization strategies that generate the highest amount of lactogenic immune protection against PEDV in suckling piglets. Because pregnancy-associated immune alterations influence viral pathogenesis and adaptive immune responses in many different species, a better understanding of host immune responses to PEDV in pregnant swine may translate into improved maternal immunization strategies against enteric pathogens for multiple species. In this review, we discuss the role of host factors during pregnancy on antiviral immunity and their implications for generating protective lactogenic immunity in suckling neonates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.