ArticleJournal of neural engineering2020
Transcranial photoacoustic imaging of NMDA-evoked focal circuit dynamics in the rat hippocampus.
Article in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Automatic photoacoustic monitoring of perinatal brain hypoxia with superior sagittal sinus detection.Journal of biomedical optics · 2025Article
- Current Practice in Using Voltage Imaging to Record Fast Neuronal Activity: Successful Examples from Invertebrate to Mammalian Studies.Biosensors · 2023Review
- High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum.Ultrasonography (Seoul, Korea) · 2023Article
- Synthetic radial aperture focusing to regulate manual volumetric scanning for economic transrectal ultrasound imaging.Ultrasonics · 2023Article
- A novel design framework of synthetic radial aperture focusing for volumetric transrectal ultrasound imaging.Journal of computational design and engineering · 2022Article
- System-level optimization in spectroscopic photoacoustic imaging of prostate cancer.Photoacoustics · 2022Article
- Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal pigletsJournal of neural engineering · 2022Article
- Photoacoustic assessment of the fetal brain and placenta as a method of non-invasive antepartum and intrapartum monitoring.Experimental neurology · 2022Review
- Editorial: Advances in Optics and Acoustics Towards Translational Functional Neuroimaging.Frontiers in neuroscience · 2022Article
- A Transparent Ultrasound Array for Real-Time Optical, Ultrasound, and Photoacoustic Imaging.BME frontiers · 2022Article
- Microdialysis and microperfusion electrodes in neurologic disease monitoring.Fluids and barriers of the CNS · 2021Review
- Multi-scale optoacoustic molecular imaging of brain diseases.European journal of nuclear medicine and molecular imaging · 2021Review
- NRM 2021 Abstract Booklet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Optimization of Near-Infrared Fluorescence Voltage-Sensitive Dye Imaging for Neuronal Activity Monitoring in the Rodent Brain.Frontiers in neuroscience · 2021Article
- Transcranial Recording of Electrophysiological Neural Activity in the Rodent BrainFrontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
Abstract
objectiveWe report the transcranial functional photoacoustic (fPA) neuroimaging of N-methyl-D-aspartate (NMDA) evoked neural activity in the rat hippocampus. Concurrent quantitative electroencephalography (qEEG) and microdialysis were used to record real-time circuit dynamics and excitatory neurotransmitter concentrations, respectively. APPROACH: We hypothesized that location-specific fPA voltage-sensitive dye (VSD) contrast would identify neural activity changes in the hippocampus which correlate with NMDA-evoked excitatory neurotransmission. MAIN
resultsTranscranial fPA VSD imaging at the contralateral side of the microdialysis probe provided NMDA-evoked VSD responses with positive correlation to extracellular glutamate concentration changes. qEEG validated a wide range of glutamatergic excitation, which culminated in focal seizure activity after a high NMDA dose. We conclude that transcranial fPA VSD imaging can distinguish focal glutamate loads in the rat hippocampus, based on the VSD redistribution mechanism which is sensitive to the electrophysiologic membrane potential. SIGNIFICANCE: Our results suggest the future utility of this emerging technology in both laboratory and clinical sciences as an innovative functional neuroimaging modality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.