Evidence map›Paper›PMID 32084360›Full record

ArticleDevelopmental cell2020

Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression.

Timothy Marsh, Candia M Kenific, Deepthisri Suresh, Hugo Gonzalez, Eliah R Shamir, Wenbin Mei, Alexandra Tankka, Andrew M Leidal, Sandhya Kalavacherla, Kimberly Woo and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 116 citations in OpenAlex.

  1. Article
  2. Autophagy modulation in cancer.Nature reviews. Drug discovery · 2026
    Review
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  16. Autophagy: The convergence point of aging and cancer.Biochemistry and biophysics reports · 2025
    Review
  17. The IPBiochimica et biophysica acta. Molecular basis of disease · 2025
    Article
  18. Review
  19. Review
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Timothy MarshDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Biomedical Sciences Graduate program, University of California, San Francisco, San Francisco, CA 94143, USA.
Candia M KenificDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Biomedical Sciences Graduate program, University of California, San Francisco, San Francisco, CA 94143, USA.
Deepthisri SureshDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Hugo GonzalezDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Eliah R ShamirDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Wenbin MeiDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Alexandra TankkaDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Andrew M LeidalDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Sandhya KalavacherlaDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Kimberly WooDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Zena WerbHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Biomedical Sciences Graduate program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Jayanta DebnathDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: jayanta.debnath@ucsf.edu.
University of California, San Francisco · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4M
Role of Metalloproteinases in Mammary Gland RemodelingR01CA057621 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 1993 to 2017
$9.0M
Autophagy in Adhesion and MetastasisR01CA126792 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jayanta Debnath · 2009 to 2026
$5.3M
Autophagy as a microenvironmental regulator of tumorigenesis and resistanceR01CA188404 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BERGERS, GABRIELE, DEBNATH, JAYANTA · 2014 to 2018
$2.1M
Stromal Fibroblast Autophagy In Tumor Progression and DesmoplasiaR01CA213775 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEBNATH, JAYANTA · 2018 to 2022
$1.9M
Deciphering Autophagy-Dependent Secretion In Cancer Via Proximity-Based BiotinylationR21CA201849 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEBNATH, JAYANTA · 2016 to 2017
$379k
The role of autophagy in cancer metastasisF31CA167905 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KENIFIC, CANDIA · 2012 to 2014
$104k
Autophagy restricts breast cancer metastasisF31CA217015 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARSH, TIMOTHY JOHN · 2017 to 2019
$95k
NCI NIH HHS F31 CA167905NCI NIH HHS F31 CA217015NCI NIH HHS R01 CA057621NCI NIH HHS R01 CA126792NCI NIH HHS R01 CA188404NCI NIH HHS R01 CA213775NCI NIH HHS R21 CA201849NCI NIH HHS T32 CA108462NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Although autophagy is being pursued as a therapeutic target in clinical oncology trials, its effects on metastasis, the principal cause of cancer mortality, remain unclear. Here, we utilize mammary cancer models to temporally delete essential autophagy regulators during carcinoma progression. Though genetic ablation of autophagy strongly attenuates primary mammary tumor growth, impaired autophagy promotes spontaneous metastasis and enables the outgrowth of disseminated tumor cells into overt macro-metastases. Transcriptomic analysis reveals that autophagy deficiency elicits a subpopulation of otherwise luminal tumor cells exhibiting basal differentiation traits, which is reversed upon preventing accumulation of the autophagy cargo receptor, Neighbor to BRCA1 (NBR1). Furthermore, pharmacological and genetic induction of autophagy suppresses pro-metastatic differentiation and metastatic outgrowth. Analysis of human breast cancer data reveal that autophagy gene expression inversely correlates with pro-metastatic differentiation signatures and predicts overall and distant metastasis-free survival. Overall, these findings highlight autophagy-dependent control of NBR1 as a key determinant of metastatic progression.

Indexed as

AutophagyAnimalsCells, CulturedFemaleHEK293 CellsHumansIntracellular Signaling Peptides and ProteinsMammary Neoplasms, ExperimentalMCF-7 CellsMiceMice, Inbred C57BLNeoplasm MetastasisTranscriptomeIntracellular Signaling Peptides and ProteinsNbr1 protein, mouseautophagybreast cancerchloroquineKeratin14metastasisNBR1RubiconTP63

Identifiers

PMID32084360
PMCPMC7108946
OpenAlexW3008887899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.