ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Coagulase-negative staphylococci: a 20-year study on the antimicrobial resistance profile of blood culture isolates from a teaching hospital.
Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 25 citations in OpenAlex.
- Prevalence of methicillin-resistant coagulase-negative staphylococci and their antibiotic resistance profile in Zagazig University intensive care units.Molecular biology reports · 2026Article
- Clarifying the Dual Role ofFoods (Basel, Switzerland) · 2025Review
- Evaluation of the relationship between biofilm formation and antibiotic resistance in coagulase-negative staphylococci isolated from blood cultures of intensive care unit patients.Antonie van Leeuwenhoek · 2025Article
- Evaluation of the antibacterial efficacy of combinations of Garcinia mangostana, Curcuma comosa, and Acanthus ebracteatus for acne vulgaris treatment: in Silico and in vitro validation.BMC complementary medicine and therapies · 2025Article
- Emerging Challenges in Methicillin Resistance of Coagulase-Negative Staphylococci.Antibiotics (Basel, Switzerland) · 2025Article
- The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials.Scientific reports · 2025Article
- Article
- Rise in the Pathogenic Status of Coagulase-Negative Staphylococci Causing Bloodstream Infection.Cureus · 2024Article
- Article
- Review
- Post-splenectomy native valve endocarditis caused by coagulase negative staphylococci: A rare case report.Annals of medicine and surgery (2012) · 2022Article
- Highly Synergistic Effects of Melittin With Vancomycin and Rifampin Against Vancomycin and Rifampin ResistantFrontiers in microbiology · 2022Article
- Virulence Factors in Coagulase-Negative Staphylococci.Pathogens (Basel, Switzerland) · 2021Review
- Incidence and characteristics of methicillin-resistant coagulase-negative Staphylococcus aureus in peritoneal dialysis-associated peritonitis in a single center using molecular methods.International urology and nephrology · 2021Article
- Enterotoxigenic Potential of Coagulase-Negative Staphylococci from Ready-to-Eat Food.Pathogens (Basel, Switzerland) · 2020Article
- Synergy of Linezolid with Several Antimicrobial Agents against Linezolid-Methicillin-Resistant Staphylococcal Strains.Antibiotics (Basel, Switzerland) · 2020Article
- Antibiotic Resistance andInfection and drug resistance · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing rates of nosocomial infection associated with coagulase-negative staphylococci (CoNS) were the rationale for this study, aiming to categorize oxacillin-resistant CoNS species recovered from blood culture specimens of inpatients at the UNESP Hospital das Clínicas in Botucatu, Brazil, over a 20-year period, and determine their sensitivity to other antimicrobial agents. The mecA gene was detected in 222 (74%) CoNS samples, and the four types of staphylococcal chromosomal cassette mec (SCCmec) were characterized in 19.4%, 3.6%, 54.5%, and 14.4% of specimens, respectively, for types I, II, III, and IV. Minimal inhibitory concentration (MIC) values to inhibit 50% (MIC50) and 90% (MIC90) of specimens were, respectively, 2 and >256μL/mL for oxacillin, 1.5 and 2μL/mL for vancomycin, 0.25 and 0.5μL/mL for linezolid, 0.094 and 0.19μL/mL for daptomycin, 0.19 and 0.5μL/mL for quinupristin/dalfopristin, and 0.125 and 0.38μL/mL for tigecycline. Resistance to oxacillin and tigecycline and intermediate resistance to quinupristin/dalfopristin were observed. Eight (2.7%) of all 300 CoNS specimens studied showed reduced susceptibility to vancomycin. Results from this study show high resistance rates of CoNS to antimicrobial agents, reflecting the necessity of using these drugs judiciously and controlling nosocomial dissemination of these pathogens.
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