ArticleNeuron2020
Combined Phase-Rate Coding by Persistently Active Neurons as a Mechanism for Maintaining Multiple Items in Working Memory in Humans.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Neural dynamics underlying minute-timescale persistent behaviour in the human brain.Nature human behaviour · 2026Article
- A Shared Theta-Rhythmic Process for Selective Sampling of Environmental Information and Internally Stored Information.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Brain-wide single-neuron bases of working memory for sounds in humans.bioRxiv : the preprint server for biology · 2025Article
- Unattended working memory items are coded by persistent activity in human medial temporal lobe neurons.Nature human behaviour · 2025Article
- Article
- Theta-phase locking of single neurons during human spatial memory.Nature communications · 2025Article
- Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks.Nature neuroscience · 2025Article
- Lack of context modulation in human single neuron responses in the medial temporal lobe.Cell reports · 2025Article
- Theta phase precession supports memory formation and retrieval of naturalistic experience in humans.Nature human behaviour · 2024Article
- Oscillations in an artificial neural network convert competing inputs into a temporal code.PLoS computational biology · 2024Article
- Article
- Trained recurrent neural networks develop phase-locked limit cycles in a working memory task.PLoS computational biology · 2024Article
- Dataset of human-single neuron activity during a Sternberg working memory task.Scientific data · 2024Article
- Article
- Behavioral fluctuation reflecting theta-rhythmic activation of sequential working memory.Scientific reports · 2024Article
- A recruitment through coherence theory of working memory.Progress in neurobiology · 2023Article
- Transcerebral information coordination in directional hippocampus-prefrontal cortex network during working memory based on bimodal neural electrical signals.Cognitive neurodynamics · 2022Article
- Cortical Ripples during NREM Sleep and Waking in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Fronto-medial theta coordinates posterior maintenance of working memory content.Current biology : CB · 2022Article
- Properties and hemispheric differences of theta oscillations in the human hippocampus.Hippocampus · 2022Article
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4 authors.
Funding
Abstract
Maintaining multiple items in working memory (WM) is central to human behavior. Persistently active neurons are thought to be a mechanism to maintain WMs, but it remains unclear how such activity is coordinated when multiple items are kept in memory. We show that memoranda-selective persistently active neurons in the human medial temporal lobe phase lock to ongoing slow-frequency (1-7 Hz) oscillations during WM maintenance. The properties of phase locking are dependent on memory content and load. During high memory loads, the phase of the oscillatory activity to which neurons phase lock provides information about memory content not available in the firing rate of the neurons. We provide a computational model that reveals that inhibitory-feedback-mediated competition between multiple persistently active neurons reproduces this phenomenon. This work reveals a mechanism for the active maintenance of multiple items in WM that relies on persistently active neurons whose activation is orchestrated by oscillatory activity.
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