Evidence map›Paper›PMID 32084325›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Mural Cell SDF1 Signaling Is Associated with the Pathogenesis of Pulmonary Arterial Hypertension.

Ke Yuan, Yu Liu, Yue Zhang, Abinaya Nathan, Wen Tian, Joyce Yu, Andrew J Sweatt, Elya A Shamshou, David Condon, Ananya Chakraborty and 7 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. A Cross-Species and Sex-Specific Meta-Analysis of Transcriptomic Studies of Pulmonary Hypertension.American journal of respiratory cell and molecular biology · 2025
    Pooled it
  2. Review
  3. Article
  4. Pericytes and Lung Vascular Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. BMP9 regulates the endothelial secretome to drive pulmonary hypertension.bioRxiv : the preprint server for biology · 2025
    Article
  9. Review
  10. Article
  11. Deciphering the Complexities of Pulmonary Hypertension: The Emergent Role of Single-Cell Omics.American journal of respiratory cell and molecular biology · 2025
    Review
  12. Article
  13. Article
  14. When a DEAD-Box Protein Is the Key: A Novel Role for DDX5 in Lung Pericyte Dysfunction.American journal of respiratory cell and molecular biology · 2024
    Article
  15. Article
  16. Role of Sensory Nerves in Pulmonary Fibrosis.International journal of molecular sciences · 2024
    Review
  17. Article
  18. Article
  19. Pulmonary Hypertension: A Contemporary Review.American journal of respiratory and critical care medicine · 2023
    Review
  20. Biology and function of pericytes in the vascular microcirculation.Animal models and experimental medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Ke YuanDivision of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts.
Yu LiuStanford Cardiovascular Institute.
Yue ZhangDepartment of Genetics.
Abinaya NathanStanford Cardiovascular Institute.
Wen TianStanford Cardiovascular Institute.
Joyce YuStanford Cardiovascular Institute.
Andrew J SweattStanford Cardiovascular Institute.
Elya A ShamshouDepartment of Immunology, University of Washington, Seattle, Washington.
David CondonDivision of Pulmonary and Critical Care Medicine.
Ananya ChakrabortyStanford Cardiovascular Institute.
Stuti AgarwalStanford Cardiovascular Institute.
Natasha AuerStanford Cardiovascular Institute.
Serena ZhangStanford Cardiovascular Institute.
Joseph C WuStanford Cardiovascular Institute.
Roham T ZamanianStanford Cardiovascular Institute.
Mark R NicollsStanford Cardiovascular Institute.
Vinicio A de Jesus PerezStanford Cardiovascular Institute.
Cardiovascular Institute of the South · USVA Palo Alto Health Care System · USBoston Children's Hospital · USPulmonary and Critical Care Associates · USUniversity of Washington · US

Funding

VRAC and Rho in pulmonary EC proliferationP01HL014985 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STENMARK, KURT R. · 1985 to 2019
$35.1M
VECTOR COREP30NS069375 · NINDS · STANFORD UNIVERSITY · PI SHAMLOO, MEHRDAD · 2011 to 2019
$6.3M
Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated CardiomyopathyR01HL141371 · NHLBI · STANFORD UNIVERSITY · PI WONG, WING H., WU, JOSEPH C. · 2018 to 2025
$6.2M
Single Cell Sequencing of Human iPSC-CM Subtype Identity and FunctionR01HL145676 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA, Joseph C. Wu · 2019 to 2026
$5.1M
The Wnt7a/ROR2 axis in the pathogenesis of pulmonary arterial hypertensionR01HL134776 · NHLBI · STANFORD UNIVERSITY · PI DE JESUS PEREZ, VINICIO A · 2017 to 2025
$5.0M
Endothelial-pericyte interactions in the pathogenesis of pulmonary arterial hypertensionR01HL139664 · NHLBI · STANFORD UNIVERSITY · PI DE JESUS PEREZ, VINICIO A · 2018 to 2025
$4.7M
Molecular Imaging of Cardiac Pluripotent Stem CellsR01HL133272 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2016 to 2020
$2.4M
The role of the Wnt5a/ROR2 in the pathogenesis of pulmonary arterial hypertension.R03HL133423 · NHLBI · STANFORD UNIVERSITY · PI DE JESUS PEREZ, VINICIO A · 2016 to 2017
$159k
NHLBI NIH HHS P01 HL014985NHLBI NIH HHS R01 HL133272NHLBI NIH HHS R01 HL134776NHLBI NIH HHS R01 HL139664NHLBI NIH HHS R01 HL141371NHLBI NIH HHS R01 HL145676NHLBI NIH HHS R03 HL133423NINDS NIH HHS P30 NS069375
6 · The paper itself

Abstract

Pulmonary artery smooth muscle cells (PASMCs) and pericytes are NG2

Indexed as

AnimalsAntigensBenzylaminesCell DivisionCell LineageChemokine CXCL12Chondroitin Sulfate Proteoglycan 4Chronic DiseaseCyclamsDNA NucleotidylexotransferaseGene Expression RegulationGene Knockdown TechniquesHeterocyclic CompoundsHypertension, PulmonaryHypoxiaMiceAntigensBenzylaminesChemokine CXCL12Chondroitin Sulfate Proteoglycan 4Cxcl12 protein, mouseCXCR4 protein, mouseCyclamsDNA NucleotidylexotransferaseHeterocyclic CompoundsplerixaforProteoglycansReceptors, CXCR4Recombinant ProteinsRNA, Messengerpericytespulmonary arterial hypertensionsmooth muscle cellsstromal cell–derived factor-1vascular remodeling

Identifiers

PMID32084325
PMCPMC7258825
OpenAlexW3007137881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.