ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020
Synthetic Ellagic Acid Glycosides Inhibit Early Stage Adhesion of Streptococcus agalactiae Biofilms as Observed by Scanning Electron Microscopy.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Valorization of polyphenolic compounds from food industry by-products for application in polysaccharide-based nanoparticles.Frontiers in nutrition · 2023Review
- Evaluation of Polyphenolic Composition and Antimicrobial Properties ofPlants (Basel, Switzerland) · 2022Article
- Recent advances on human milk oligosaccharide antimicrobial activity.Current opinion in chemical biology · 2022Review
- Optimization ofPathogens (Basel, Switzerland) · 2021Article
- Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology.Molecules (Basel, Switzerland) · 2021Review
- Liposomal Ellagic Acid Alleviates Cyclophosphamide-Induced Toxicity and Eliminates the SystemicPharmaceutics · 2021Article
- Leveraging Stereoelectronic Effects in Biofilm Eradication: Synthetic β-Amino Human Milk Oligosaccharides Impede Microbial Adhesion As Observed by Scanning Electron Microscopy.The Journal of organic chemistry · 2020Article
- Natural products as inspiration for the development of bacterial antibiofilm agents.Natural product reports · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Ellagic acid derivatives possess antimicrobial and antibiofilm properties across a wide-range of microbial pathogens. Due to their poor solubility and ambident reactivity it is challenging to synthesize, purify, and characterize the activity of ellagic acid glycosides. In this study, we have synthesized three ellagic acid glycoconjugates and evaluated their antimicrobial and antibiofilm activity in Streptococcus agalactiae (Group B Streptococcus, GBS). Their significant impacts on biofilm formation were examined via SEM to reveal early-stage inhibition of cellular adhesion. Additionally, the synthetic glycosides were evaluated against five of the six ESKAPE pathogens and two fungal pathogens. These studies reveal that the ellagic acid glycosides possess inhibitory effects on the growth of gram-negative pathogens.
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Registered trials
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