Evidence map›Paper›PMID 32084294›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

A Sequential Umpolung/Enzymatic Dynamic Kinetic Resolution Strategy for the Synthesis of γ-Lactones.

Mark A Maskeri, Malte L Schrader, Karl A Scheidt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Oxidant-Free Amidation of Aldehydes Enabled by Electrophotocatalysis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  2. Review
  3. Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β-Hydroxyketones.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mark A MaskeriDepartment of Chemistry, Center for Molecular Innovation and Drug Discovery, Northwestern University, Silverman Hall, Evanston, Illinois, 60208, USA.
Malte L SchraderDepartment of Chemistry, Center for Molecular Innovation and Drug Discovery, Northwestern University, Silverman Hall, Evanston, Illinois, 60208, USA.
Karl A ScheidtDepartment of Chemistry, Center for Molecular Innovation and Drug Discovery, Northwestern University, Silverman Hall, Evanston, Illinois, 60208, USA.ORCID http://orcid.org/0000-0003-4856-3569

Funding

Supplement to Carbene Catalysis Strategies for Organic SynthesisR01GM073072 · NIGMS · NORTHWESTERN UNIVERSITY · PI SCHEIDT, KARL A · 2006 to 2018
$4.0M
New Acid Catalysis Concepts for Asymmetric SynthesisR01GM131431 · NIGMS · NORTHWESTERN UNIVERSITY · PI SCHEIDT, KARL A · 2019 to 2019
$305k
NIGMS NIH HHS GM073072NIGMS NIH HHS R01 GM073072NIGMS NIH HHS R01 GM131431
6 · The paper itself

Abstract

Combining biological and small-molecule catalysts under a chemoenzymatic manifold presents a series of significant advantages to the synthetic community. We report herein the successful development of a two-step/single flask synthesis of γ-lactones through the merger of Umpolung catalysis with a ketoreductase-catalyzed dynamic kinetic resolution, reduction, and cyclization. This combined approach delivers highly enantio- and diastereoenriched heterocycles and demonstrates the feasibility of integrating NHC catalysis with enzymatic processes.

Indexed as

CatalysisCyclizationKineticsLactonesMolecular StructureLactoneschemoenzymatic catalysisketoreductase enzymeN-heterocyclic carbene catalysisphotoredox catalysissequential catalysis

Identifiers

PMID32084294
PMCPMC7210063

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.