ArticlePloS one2020
Using comparative genomics to understand molecular features of carbapenem-resistant Acinetobacter baumannii from South Korea causing invasive infections and their clinical implications.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Clonal Dynamics and Antimicrobial Resistance of Bloodstream Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Genomic Epidemiology of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Comprehensive in silico analysis of Acinetobacter isolates from South Korea reveals genomic diversity, antimicrobial resistance, virulence factors, and evolutionary dynamics.Genes & genomics · 2026Article
- An Overview of the Epidemiology of Multidrug Resistance and Bacterial Resistance Mechanisms: What Solutions Are Available? A Comprehensive Review.Microorganisms · 2025Review
- Molecular genotyping reveals multiple carbapenemase genes and unique blaTropical medicine and health · 2024Article
- The Distribution of Carbapenem-Resistant Acinetobacter Species and High Prevalence of CC92 OXA-23-ProducingInfection and drug resistance · 2024Article
- Molecular and virulence characteristics of carbapenem-resistant Acinetobacter baumannii isolates: a prospective cohort study.Scientific reports · 2023Article
- The Changes in Epidemiology of Imipenem-ResistantJournal of Korean medical science · 2022Article
- Whole-genome analysis of carbapenem-resistantComputational and structural biotechnology journal · 2022Article
- Replacement of the Dominant ST191 Clone by ST369 Among Carbapenem-ResistantFrontiers in microbiology · 2022Article
- Adverse clinical outcomes associated with carbapenem-resistantJAC-antimicrobial resistance · 2021Review
- Antibiotic Resistance and Genotypes of Nosocomial Strains ofAntibiotics (Basel, Switzerland) · 2021Article
- Analysis ofInternational journal of molecular sciences · 2021Article
- Whole-Genome Sequencing for Investigating a Health Care-Associated Outbreak of Carbapenem-ResistantDiagnostics (Basel, Switzerland) · 2021Article
- Whole genome analysis revealed the role ofPathogens and global healthArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acinetobacter baumannii is a highly potent nosocomial pathogen that is associated with increased in-hospital mortality. Here, we investigated the changes in molecular characteristics of carbapenem-resistant A. baumannii (CRAB) isolated from the blood samples of patients admitted to a tertiary hospital in South Korea from January 2009 to July 2015. Whole genome sequencing using the Illumina MiSeq platform and multi-locus sequence typing (MLST) were performed for 98 CRAB clinical isolates. In silico analyses for the prediction of antimicrobial resistance and virulence factor genes were performed. Plasmid sequences, including complete forms, were reconstructed from the sequence reads. Epidemiologic data were collected from the hospital database. MLST using the Oxford scheme revealed 10 sequence types of CRAB, of which ST191 was the dominant type (n = 59). Although blaOXA-23 was shared by most analysed strains, the compositions of antimicrobial resistance determinants differed among sequence types. ST447 and ST451/ST1809 with a few resistance genes were isolated during the later years of the study period. The number of virulence genes increased, while that of ST191 did not change significantly over the investigation period. Intriguingly MLST types, compositions of antimicrobial resistance genes, and virulence genes had no association with clinical outcomes of CRAB bacteraemia. In conclusion, active changes in or accumulations of antimicrobial resistance determinants and virulence genes in CRAB were not observed during the research period. Molecular characteristics of CRAB had no association with clinical outcomes of CRAB bacteraemia.
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