ArticlePloS one2020
The contribution of sGAGs to stress-controlled tensile response of posterior porcine sclera.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Decellularization method and tissue region impact the structural properties and composition of porcine vaginal extracellular matrix.Acta biomaterialia · 2026Article
- Microindentation reveals softening of the equatorial and anterior sclera during early myopia development in tree shrew eyes.Acta biomaterialia · 2025Article
- A direct fiber approach to model sclera collagen architecture and biomechanics.Experimental eye research · 2023Article
- Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell.Experimental eye research · 2023Article
- On the Mechanical Roles of Glycosaminoglycans in the Tensile Properties of Porcine Corneal Stroma.Investigative ophthalmology & visual science · 2023Article
- Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia.Investigative ophthalmology & visual science · 2022Article
- Tensile Viscoelastic Properties of the Sclera after Glycosaminoglycan Depletion.Current eye research · 2021Article
- Glaucoma in mucopolysaccharidoses.Orphanet journal of rare diseases · 2021Review
- Regional Differences in the Glycosaminoglycan Role in Porcine Scleral Hydration and Mechanical Behavior.Investigative ophthalmology & visual science · 2021Article
- Collagen fiber interweaving is central to sclera stiffness.Acta biomaterialia · 2020Article
- Mucopolysaccharidosis.Taiwan journal of ophthalmologyReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the significant progress in characterizing mechanical functions of individual scleral extracellular matrix (ECM) components, the biomechanical contribution of sulfated glycosaminoglycans (sGAGs) is still poorly understood. The primary purpose of this study was to determine the possible function of sGAGs in scleral mechanical response by characterizing the tensile behavior of normal and sGAG-depleted samples. We used chondroitinase ABC solution to remove sGAGs from scleral samples that were dissected from posterior porcine eyes. We performed biochemical analyses for assessing the efficacy of sGAG removal protocol. Furthermore, we conducted stress-controlled uniaxial tensile tests to characterize the influence of sGAG removal on mechanical properties of sclera. The tensile behavior of scleral strips right after dissection and after being soaked in buffer was also determined. Biochemical analyses confirmed that 18 hour incubation in 0.125 U/ml Chondroitinase ABC solution removed over 90% of chondroitin and dermatan sGAGs. No significant difference was observed in the thickness/hydration of samples because of enzyme- and buffer-treated samples. Furthermore, it was found that sGAG depletion did not significantly alter the tangent modulus, energy dissipation, and peak strain of posterior scleral strips. It was concluded that sGAGs did not influence the stress-controlled viscoelastic tensile response of sclera.
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