ArticleThe Journal of the Association of Nurses in AIDS Care : JANAC
Associations Between Influencing Factors, Perceived Symptom Burden, and Perceived Overall Function Among Adults Living With HIV.
Article in The Journal of the Association of Nurses in AIDS Care : JANAC. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Structural equation analysis of rural communities in South Africa and Nigeria: social determinants of health, nutritional deficiencies, and perceived HIV symptoms.Frontiers in public health · 2026Article
- The Impact of Childhood Household Violence on HIV-Related Outcomes in People With HIV in the United States: The Role of Psychological Distress and Social Stressors.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Trajectories of Symptom Clusters and Their Predictive Factors in Patients With Colorectal Cancer 3 Months After Surgery: A Longitudinal Study.Cancer medicine · 2025Observational
- High Symptom Burden in Patients With Advanced Chronic or Prolonged Infectious Diseases: Not Only Pain.Cureus · 2024Article
- Self-Reported Health-Related Quality of Life and Residual Symptoms among Virologically Suppressed People Living with HIV in the Era of Single-Tablet Regimens in Taiwan: A Cross-Sectional Study.Life (Basel, Switzerland) · 2024Article
- Prevalence of pain in women living with HIV aged 45-60: associated factors and impact on patient-reported outcomes.AIDS care · 2023Article
- Problems undermining the health-related quality of life of people living with HIV in Spain: a qualitative study to inform the development of a novel clinic screening tool.Health and quality of life outcomes · 2022Review
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Authors and funding
5 authors.
Funding
Abstract
With adherence to combination antiretroviral therapy, HIV infection is now a chronic, but manageable, disease with associated symptoms and complications. However, there is limited evidence on how symptom burden affects perceived overall function among people living with HIV (PLWH). Furthermore, there is no consensus on the factors that affect symptom burden in PLWH. We examined relationships between factors that may influence symptom burden and perceived overall function, and the association between symptom burden and overall function in 179 adult PLWH. This study was a cross-sectional, secondary analysis using the Theory of Unpleasant Symptoms (Lenz, Pugh, Milligan, Gift, & Suppe, 1997). We found strong evidence that symptoms, especially pain, tiredness, and depression, are prevalent in PLWH, and that symptoms were predicted by perceived social support and the number of comorbidities. Increased symptom burden predicts reduced overall function. Interventions are needed to reduce symptoms and strengthen social support in PLWH. Initiating symptom assessment and management strategies early is paramount.
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Registered trials
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