Evidence map›Paper›PMID 32084011›Full record

ArticleAging2020

Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota.

Jianfeng Liu, Tianhua Zhang, Yingying Wang, Chengqing Si, Xudong Wang, Rui-Tao Wang, Zhonghua Lv

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jianfeng LiuDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Tianhua ZhangDepartment of Vascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Yingying WangDepartment of Computer Science, Hong Kong Baptist University, Hong Kong, China.
Chengqing SiDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Xudong WangDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Rui-Tao WangDepartment of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, China.
Zhonghua LvDepartment of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, China.
Harbin Medical University · CNThird Affiliated Hospital of Harbin Medical University · CNHong Kong Baptist University · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the neuroprotective effects of baicalin and the role of gut microbiota in a mouse model of cerebral ischemia-reperfusion injury. Repeated cerebral ischemia-reperfusion significantly increased plasma levels of trimethylamine (TMA), trimethylamine-

Indexed as

AnimalsBrainClusterinCytokinesDisease Models, AnimalFlavonoidsGastrointestinal MicrobiomeInflammationMaleMethylaminesMiceNeuronsNeuroprotective AgentsReperfusion InjurybaicalinClusterinCytokinesFlavonoidsMethylaminesNeuroprotective Agentstrimethylaminetrimethyloxaminebaicalincerebral ischemia-reperfusioncognitive behaviorgut microbiota

Identifiers

PMID32084011
PMCPMC7066900
OpenAlexW3008274783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.