Evidence map›Paper›PMID 32083993›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2020

Growth Rates of Genetically Defined Renal Tumors: Implications for Active Surveillance and Intervention.

Mark W Ball, Julie Y An, Patrick T Gomella, Rabindra Gautam, Christopher J Ricketts, Cathy D Vocke, Laura S Schmidt, Maria J Merino, Ramaprasad Srinivasan, Ashkan A Malayeri and 2 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

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  17. Hereditary Renal Cancer Syndromes.Medical sciences (Basel, Switzerland) · 2024
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Mark W BallUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
Julie Y AnUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
Patrick T GomellaUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
Rabindra GautamUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
Christopher J RickettsUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
Cathy D VockeUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
Laura S SchmidtBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD.
Maria J MerinoUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
Ramaprasad SrinivasanUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
Ashkan A MalayeriUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
Adam R MetwalliUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
W Marston LinehanUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
Center for Cancer Research · USNational Cancer Institute · USFrederick National Laboratory for Cancer Research · US

Funding

Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase GeneZIABC011038 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LINEHAN, WILLIAM MARSTON · 2009 to 2025
$29.8M
Molecular Therapeutics of Kidney Cancer: MET Gene and BHD GeneZIABC011043 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LINEHAN, WILLIAM MARSTON · 2009 to 2025
$20.9M
Clinical Studies of the Molecular Genetic Basis of Kidney CancerZIABC011028 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LINEHAN, WILLIAM MARSTON · 2009 to 2025
$17.9M
Clinical Nursing and Data Management CoreZIDBC011089 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LINEHAN, WILLIAM MARSTON · 2009 to 2025
$17.4M
Tissue ProcessingSequencing FacilityZICBC011044 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI VOCKE, CATHY D · 2009 to 2025
$13.5M
Targeting Genetic and Metabolic Alterations in Distinct Subtypes of RCCZIABC011648 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SRINIVASAN, RAMAPRASAD · 2015 to 2025
$12.2M
Novel Approaches to Targeting Cancers Associated with VHL MutationsZIABC011920 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SRINIVASAN, RAMAPRASAD · 2019 to 2025
$4.1M
microRNA Profiling in the Spectrum of Kidney TumorsZIABC011405 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MERINO, MARIA · 2011 to 2025
$2.9M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

purposePublished series of growth rates of renal tumors on active surveillance largely consist of tumors without pathologic or genetic data. Growth kinetics of genetically defined renal tumors are not well known. Here, we evaluate the growth of genetically defined renal tumors and their association with patient clinical and genetic characteristics. PATIENTS AND

methodsWe evaluated patients with an inherited kidney cancer susceptibility syndrome as a result of a pathologic germline alteration of

resultsA total of 292 patients with 435 genetically defined tumors were identified, including 286

conclusionIn a cohort of genetically defined tumors, tumor growth rates varied in a clinically and statistically different manner according to genetic subtype. Rapid growth of

Indexed as

AdultAgedAge FactorsCell ProliferationFemaleHumansKidney NeoplasmsMaleMiddle AgedProto-Oncogene ProteinsProto-Oncogene Proteins c-metTumor Suppressor ProteinsUbiquitin ThiolesteraseVon Hippel-Lindau Tumor Suppressor ProteinBAP1 protein, humanFLCN protein, humanMET protein, humanProto-Oncogene ProteinsProto-Oncogene Proteins c-metTumor Suppressor ProteinsUbiquitin ThiolesteraseVHL protein, humanVon Hippel-Lindau Tumor Suppressor Protein

Identifiers

PMID32083993
PMCPMC7145590
OpenAlexW3008992303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.