Evidence map›Paper›PMID 32083846›Full record

ArticleAnalytical chemistry2020

Localization of Metabolites of Human Kidney Tissue with Infrared Laser-Based Selected Reaction Monitoring Mass Spectrometry Imaging and Silver-109 Nanoparticle-Based Surface Assisted Laser Desorption/Ionization Mass Spectrometry Imaging.

Joanna Nizioł, Jan Sunner, Iwona Beech, Krzysztof Ossoliński, Anna Ossolińska, Tadeusz Ossoliński, Aneta Płaza, Tomasz Ruman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Broadband Collision-Induced Dissociation Mass Spectrometry Imaging.Journal of the American Society for Mass Spectrometry · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2023
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Metabolomic and elemental profiling of human tissue in kidney cancer.Metabolomics : Official journal of the Metabolomic Society · 2021
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Joanna NiziołRzeszów University of Technology, Faculty of Chemistry, 6 Powstańców Warszawy Ave., Rzeszów, 35-959, Poland.ORCID 0000-0002-4783-8615
Jan SunnerCenter for Biofilm Engineering, Montana State University, 366 Barnard Hall, Bozeman, Montana 59717-3980, United States.
Iwona BeechCenter for Biofilm Engineering, Montana State University, 366 Barnard Hall, Bozeman, Montana 59717-3980, United States.
Krzysztof OssolińskiDepartment of Urology, John Paul II Hospital, Grunwaldzka 4 St., Kolbuszowa, 36-100, Poland.
Anna OssolińskaDepartment of Urology, John Paul II Hospital, Grunwaldzka 4 St., Kolbuszowa, 36-100, Poland.
Tadeusz OssolińskiDepartment of Urology, John Paul II Hospital, Grunwaldzka 4 St., Kolbuszowa, 36-100, Poland.
Aneta PłazaDoctoral School of Engineering and Technical Sciences at the Rzeszów University of Technology, 8 Powstańców Warszawy Ave., Rzeszów, 35-959, Poland.
Tomasz RumanRzeszów University of Technology, Faculty of Chemistry, 6 Powstańców Warszawy Ave., Rzeszów, 35-959, Poland.ORCID 0000-0002-9899-8627
John Paul II Hospital · PLRzeszów University of Technology · PLMontana State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infrared (IR) laser ablation-remote-electrospray ionization (LARESI) platform coupled to a tandem mass spectrometer (MS/MS) operated in selected reaction monitoring (SRM) or multiple reaction monitoring (MRM) modes was developed and employed for imaging of target metabolites in human kidney cancer tissue. SRM or MRM modes were employed to avoid artifacts that are present in full scan MS mode. Four tissue samples containing both cancerous and noncancerous regions, obtained from three patients with renal cell carcinoma (RCC), were imaged. Sixteen endogenous metabolites that were reported in the literature as varying in abundance between cancerous and noncancerous areas in various human tissues were selected for analysis. Target metabolites comprised ten amino acids, four nucleosides and nucleobases, lactate, and vitamin E. For comparison purposes, images of the same metabolites were obtained with ultraviolet (UV) desorption/ionization mass spectrometry imaging (UV-LDI-MSI) using monoisotopic silver-109 nanoparticle-enhanced target (

Indexed as

Optical ImagingAmino AcidsCarcinoma, Renal CellHumansKidney NeoplasmsLactic AcidLasersMass SpectrometryMetal NanoparticlesNucleosidesSilverSurface PropertiesVitamin EAmino AcidsLactic AcidNucleosidesSilverVitamin E

Identifiers

PMID32083846
PMCPMC7497619
OpenAlexW3007320120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.