ArticleThe Journal of clinical endocrinology and metabolism2020
Is Midlife Metabolic Syndrome Associated With Cognitive Function Change? The Study of Women's Health Across the Nation.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolic syndrome and cognition: A systematic review across cognitive domains and a bibliometric analysis.Frontiers in psychology · 2022Pooled it
- Metabolic syndrome is associated with accelerated brain aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Effects of Changes in Metabolic Syndrome Status on Cognitive Function: A 10-Year Study in a Middle-Aged Population.The Kaohsiung journal of medical sciences · 2026Article
- Mediating Role of Plasma Biomarkers Associated with Metabolic Syndrome in Cognitive Decline Among Older Adults.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Association of metabolic syndrome severity with cognitive decline among Chinese older adults: evidence from two prospective cohort studies.Frontiers in neuroscience · 2026Article
- The Association Between Hypothyroidism and Cognitive Function Change in Women across the Menopause Transition: The Study of Women's Health Across the Nation.Thyroid : official journal of the American Thyroid Association · 2024Article
- Metabolic Syndrome Status Changes and Cognitive Functioning: Insights from the Lifelines Cohort Study.The journal of prevention of Alzheimer's disease · 2024Article
- Bridging metabolic syndrome and cognitive dysfunction: role of astrocytes.Frontiers in endocrinology · 2024Review
- Metabolic syndrome and cognitive deficits in the Greek cohort of Epirus Health Study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Pragmatic approaches to handling practice effects in longitudinal cognitive aging research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Brain sex-dependent alterations after prolonged high fat diet exposure in mice.Communications biology · 2022Article
- A flexible approach for variable selection in large-scale healthcare database studies with missing covariate and outcome data.BMC medical research methodology · 2022Article
- Rural-urban and gender differences in metabolic syndrome in the aging population from southern India: Two parallel, prospective cohort studies.EClinicalMedicine · 2022Article
- The Metabolic Syndrome Is Associated With Lower Cognitive Performance and Reduced White Matter Integrity in Midlife: The CARDIA Study.Frontiers in neuroscience · 2022Article
- The Association Between Diet and Cardio-Metabolic Risk on Cognitive Performance: A Cross-Sectional Study of Middle-Aged Australian Adults.Frontiers in nutrition · 2022Article
- Variable selection with missing data in both covariates and outcomes: Imputation and machine learning.Statistical methods in medical research · 2021Article
- Predictors of cognitive decline in a multi-racial sample of midlife women: A longitudinal study.Neuropsychology · 2021Article
- Acculturation in Context: The Relationship Between Acculturation and Socioenvironmental Factors With Level of and Change in Cognition in Older Latinos.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Metabolic Syndrome and Physical Performance: The Moderating Role of Cognition among Middle-to-Older-Aged Adults.Journal of the International Neuropsychological Society : JINS · 2021Article
- Relationship Between Metabolic Syndrome and Cognitive Function: A Population-Based Study of Middle-Aged and Elderly Adults in Rural China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
contextMetabolic syndrome (MetS) affects cognitive function in late life, particularly in women. But longitudinal research is scarce on associations of MetS with cognitive function during midlife.
objectiveTo determine associations between MetS exposure and cognitive function trajectories in midlife women. DESIGN AND
settingThis is a 17-year prospective, longitudinal study of multiracial/ethnic women in 7 US communities, with annual/biennial assessments.
participantsParticipants were 2149 US women traversing menopause. EXPOSURE: Exposure consisted of MetS assessments (median 4 assessments over 4 years).
main outcome measuresMain outcome measures were assessments of cognitive function in 3 domains: perceptual speed (symbol digit modalities test, SDMT), episodic memory (East Boston Memory Test, EBMT), and working memory (Digit Span Backward Test, DSB).
resultsBy their first cognitive assessment (age 50.7 ± 2.9 years), 29.5% met the criteria for MetS. Women completed a median (interquartile range [IQR]) of 6 (IQR 4-7) follow-up cognitive assessments over 11.2 (IQR 9.2-11.5) years. Women with MetS, compared with those without, had a larger 10-year decline in SDMT z-score (estimate -0.087, 95% confidence interval, -0.150 to -0.024; P = 0.007), after adjustment for cognitive testing practice effects, sociodemographics, lifestyle, mood, and menopause factors. As such, MetS accelerated the 10-year loss of perceptual speed by 24%. MetS did not differentially affect the rate of decline in either immediate (P = 0.534) or delayed (P = 0.740) episodic memory or in working memory (P = 0.584).
conclusionsIn midlife women MetS exposure was associated with accelerated decline in perceptual speed, but not episodic or working memory.
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