Evidence map›Paper›PMID 32083613›Full record

ArticleClinical kidney journal2020

Frailty is independently associated with worse health-related quality of life in chronic kidney disease: a secondary analysis of the Frailty Assessment in Chronic Kidney Disease study.

Andrew C Nixon, Theodoros M Bampouras, Neil Pendleton, Sandip Mitra, Mark E Brady, Ajay P Dhaygude

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Association Between Frailty and Cognitive Impairment in Chronic Kidney Disease: A Systematic Review and Meta-Analysis.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026
    Pooled it
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  7. The Battle for Beds before Health: Unpacking the Crisis of Healthcare in Ghana's Low-Income Communities.Journal of urban health : bulletin of the New York Academy of Medicine · 2026
    Article
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  13. Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
    Review
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  15. Influence of frailty status on the health-related quality of life in older patients with chronic low back pain: a retrospective observational study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Andrew C NixonDepartment of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston,UK.ORCID 0000-0002-4093-6204
Theodoros M BampourasActive Ageing Research Group, University of Cumbria, Lancaster, UK.
Neil PendletonDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
Sandip MitraManchester Academy of Health Sciences Centre, University of Manchester, Manchester, UK.
Mark E BradyDepartment of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston,UK.
Ajay P DhaygudeDepartment of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston,UK.
Lancashire Teaching Hospitals NHS Foundation Trust · GBLancaster University · GBManchester Academic Health Science Centre · GBUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Understanding how frailty affects health-related quality of life (HRQOL) in those with chronic kidney disease (CKD) could assist in the development of management strategies to improve outcomes for this vulnerable patient group. This study aimed to evaluate the relationship between frailty and HRQOL in patients with CKD Stages 4 and 5 (G4–5) and those established on haemodialysis (G5D). Methods: Ninety participants with chronic kidney disease (CKD G4–5D) were recruited between December 2016 and December 2017. Frailty was assessed using the Frailty Phenotype, which included assessments of unintentional weight loss, weakness (handgrip strength), slowness (walking speed), physical activity and self-perceived exhaustion. HRQOL was assessed using the RAND 36-Item Health Survey Version 1.0 (SF-36). Results: Nineteen (21%) patients were categorized as frail. Frailty, when adjusted for age, gender, dialysis dependence and comorbidity, had a significant effect on five of the eight SF-36 domains: physical functioning, role limitations due to emotional problems, energy/fatigue, social functioning and pain. Regression modelling best explained the variation in the physical functioning domain (adj. R2 = 0.27, P < 0.001), with frailty leading to a 26-point lower score. Exhaustion was the only Frailty Phenotype component that had a significant effect on scores across all SF-36 domains. Conclusions: Frailty is independently associated with worse HRQOL in patients with CKD G4–5D, with self-perceived exhaustion being the most significant Frailty Phenotype component contributing to HRQOL. Efforts should be made to identify frail patients with CKD so that management strategies can be offered that aim to improve morbidity, mortality and patient-reported outcomes, including HRQOL and fatigue.

Indexed as

chronic kidney diseaseend-stage kidney diseasefrailtygeriatric nephrologyhaemodialysisquality of life

Identifiers

PMID32083613
PMCPMC7025341
OpenAlexW2942842265

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.