ArticleJournal of Alzheimer's disease : JAD2020
Circulating Progenitor Cells and Cognitive Impairment in Men and Women with Coronary Artery Disease.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Circulating Progenitor Cells, Regenerative Capacity and Cognition: Evidence From 2 Community-Based Cohorts.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- CD34+ Hematopoietic Stem Cell Counts in Alzheimer's Disease: A Meta-Analysis.Diseases (Basel, Switzerland) · 2025Review
- An Investigation of the Inflammatory Landscape in the Brain and Bone Marrow of the APP/PS1 Mouse.Journal of Alzheimer's disease reports · 2024Article
- A Pilot Study of Neurobiological Mechanisms of Stress and Cardiovascular Risk.Medical research archives · 2023Article
- CD34Neural regeneration research · 2023Article
- Circulating endothelial and angiogenic cells predict hippocampal volume as a function of HIV status.Journal of neurovirology · 2023Article
- Role of Endothelial Progenitor Cells in Frailty.International journal of molecular sciences · 2023Review
- Blood-Derived Progenitor Cells Are Depleted in Older Adults with Cognitive Impairment: A Role for Vascular Resilience?Journal of Alzheimer's disease : JAD · 2023Article
- RANK/RANKL/OPG axis genes relation to cognitive impairment in children with transfusion-dependent thalassemia: a cross-sectional study.BMC pediatrics · 2022Article
- Endothelial Progenitor Cells and Vascular Alterations in Alzheimer's Disease.Frontiers in aging neuroscience · 2021Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundCirculating progenitor cells (CPC) have been associated with memory function and cognitive impairment in healthy adults. However, it is unclear whether such associations also exist in patients with coronary artery disease (CAD).
objectiveTo assess the association between CPCs and memory performance among individuals with CAD.
methodsWe assessed cognitive function in 509 patients with CAD using the verbal and visual Memory subtests of the Wechsler memory scale-IV and the Trail Making Test parts A and B. CPCs were enumerated with flow cytometry as CD45med/CD34+ blood mononuclear cells, those co-expressing other epitopes representing populations enriched for hematopoietic and endothelial progenitors.
resultsAfter adjusting for demographic and cardiovascular risk factors, lower number of endothelial progenitor cell counts were independently associated with lower visual and verbal memory scores (p for all < 0.05). There was a significant interaction in the magnitude of this association with race (p < 0.01), such that the association of verbal memory scores with endothelial progenitor subsets was present in Black but not in non-Black participants. No associations were present with the hematopoietic progenitor-enriched cells or with the Trail Making Tests.
conclusionLower numbers of circulating endothelial progenitor cells are associated with cognitive impairment in patients with CAD, suggesting a protective effect of repair/regeneration processes in the maintenance of cognitive status. Impairment of verbal memory function was more strongly associated with lower CPC counts in Black compared to non-Black participants with CAD. Whether strategies designed to improve regenerative capacity will improve cognition needs further study.
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