Evidence map›Paper›PMID 32083462›Full record

ArticleACS chemical biology2023

Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb

Karl R Schmitz, Emma L Handy, Corey L Compton, Shashank Gupta, William R Bishai, Robert T Sauer, Jason K Sello

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Macrocyclic Peptides that Selectively Inhibit theJournal of medicinal chemistry · 2021
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Karl R SchmitzDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Emma L HandyDepartment of Chemistry, Brown University, Providence, Rhode Island 02912, United States.
Corey L ComptonDepartment of Chemistry, Brown University, Providence, Rhode Island 02912, United States.
Shashank GuptaDepartment of Chemistry, Brown University, Providence, Rhode Island 02912, United States.
William R BishaiCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, United States.
Robert T SauerDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Jason K SelloDepartment of Chemistry, Brown University, Providence, Rhode Island 02912, United States.ORCID 0000-0001-6263-7902
Brown University · USJohns Hopkins University · USMassachusetts Institute of Technology · USUniversity of California, San Francisco · US

Funding

Sequence Determinants of Protein Structure and StabilityR01GM101988 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SAUER, ROBERT T · 2012 to 2019
$3.5M
Studies of the Antibacterial Activity of and Resistance to Molecules Targeting the ClpP PeptidaseR01AI123400 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SELLO, JASON K · 2017 to 2021
$2.9M
Structure and function of ClpXPR35GM141517 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SAUER, ROBERT T · 2021 to 2024
$1.5M
NIAID NIH HHS R01 AI123400NIGMS NIH HHS R01 GM101988NIGMS NIH HHS R35 GM141517
6 · The paper itself

Abstract

Proteolytic complexes in

Indexed as

Anti-Bacterial AgentsMycobacterium tuberculosisTuberculosisAdenosine TriphosphateBacterial ProteinsDepsipeptidesEndopeptidase ClpHumansMolecular ChaperonesPeptide HydrolasesacyldepsipeptidesAdenosine TriphosphateAnti-Bacterial AgentsBacterial ProteinsclpP1 protein, Mycobacterium tuberculosisclpP2 protein, Mycobacterium tuberculosisDepsipeptidesEndopeptidase ClpMolecular ChaperonesPeptide Hydrolases

Identifiers

PMID32083462
PMCPMC7842861
OpenAlexW3006871946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.