Evidence map›Paper›PMID 32083308›Full record

ArticleJournal of neurochemistry2021

Reelin signaling modulates GABA

Mohammad I K Hamad, Abdalrahim Jbara, Obada Rabaya, Petya Petrova, Solieman Daoud, Nesrine Melliti, Maurice Meseke, David Lutz, Elisabeth Petrasch-Parwez, Jan Claudius Schwitalla and 5 more

Abstract read
In one paragraph

Article in Journal of neurochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Defining a Midgestational Window forbioRxiv : the preprint server for biology · 2026
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  12. Keeping the Balance: GABABrain sciences · 2022
    Review
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  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mohammad I K HamadDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany.ORCID 0000-0003-0198-389X
Abdalrahim JbaraDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany.
Obada RabayaDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany.
Petya PetrovaDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany.
Solieman DaoudDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany.
Nesrine MellitiDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany.
Maurice MesekeDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany.
David LutzDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany.
Elisabeth Petrasch-ParwezDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany.
Jan Claudius SchwitallaDepartment of Behavioral Neuroscience, Ruhr University Bochum, Bochum, Germany.
Melanie D MarkDepartment of Behavioral Neuroscience, Ruhr University Bochum, Bochum, Germany.
Stefan HerlitzeDepartment of Zoology and Neurobiology, Ruhr University Bochum, Bochum, Germany.
Gebhard ReissInstitute for Anatomy and Clinical Morphology, School of Medicine, Faculty of Health, Herdecke University, Witten, Witten.
Joachim HerzDepartments of Molecular Genetics, Neuroscience, Neurology and Neurotherapeutics, Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Eckart FörsterDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany.

Funding

Validation of Modulators of PGRN as Novel Therapeutics for Frontotemporal DementiR01NS108115 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI HAGGARTY, STEPHEN J, HERZ, JOACHIM J · 2018 to 2022
$4.0M
Metabolism of the VLDL receptor and ApoE receptor 2R37HL063762 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2010 to 2019
$4.0M
Physiology and Pathophysiology of Apolipoprotein E receptor-2 splicing in Alzheimer's diseaseRF1AG053391 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2016 to 2020
$2.4M
Molecular Basis of Synaptic Suppression by ApoER01NS093382 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2016 to 2020
$2.0M
Consortium for Frontotemporal Dementia ResearchFoRUM of the Ruhr-Universität BochumNHLBI NIH HHS R37 HL063762NIA NIH HHS RF1 AG053391NIH HHS R01 NS093382NIH HHS R01 NS108115NIH HHS R37 HL63762NIH HHS RF1 AG053391NINDS NIH HHS R01 NS093382NINDS NIH HHS R01 NS108115
6 · The paper itself

Abstract

Reelin is a protein that is best known for its role in controlling neuronal layer formation in the developing cortex. Here, we studied its role for post-natal cortical network function, which is poorly explored. To preclude early cortical migration defects caused by Reelin deficiency, we used a conditional Reelin knock-out (Reln

Indexed as

AnimalsAnimals, NewbornCell Adhesion Molecules, NeuronalExtracellular Matrix ProteinsFemaleGABA-B Receptor AgonistsMaleMiceMice, KnockoutNeocortexNerve Tissue ProteinsOrgan Culture TechniquesReceptors, GABA-BReelin ProteinSerine EndopeptidasesSignal TransductionCell Adhesion Molecules, NeuronalExtracellular Matrix ProteinsGABA-B Receptor AgonistsGabbr2 protein, mouseNerve Tissue ProteinsReceptors, GABA-BReelin ProteinReln protein, mouseSerine EndopeptidasesApoER2 and VLDLRcalcium imagingGABAB receptorsnetwork activityReelin

Identifiers

PMID32083308
PMCPMC7442713

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.