ArticleSchizophrenia bulletin2020
Examining Gene-Environment Interactions Using Aggregate Scores in a First-Episode Psychosis Cohort.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Environmental risk score as a predictor for 25-year symptom and functional trajectories in first episode psychosis.medRxiv : the preprint server for health sciences · 2026Article
- Multimodal prediction of psychotic-like experiences using elastic net modeling: external validation in a clinical sample.Psychological medicine · 2025Article
- Effects of parental characteristics on the risk of psychopathology in offspring: a 4-year follow-up study.European child & adolescent psychiatry · 2025Article
- Combining the Risk: The Poly-Environmental Risk Score and Psychotic Symptoms in Adolescents.Schizophrenia bulletin · 2025Article
- Recent findings and future directions for the intersection of genetic and environmental contributions to schizophrenia.Genomic psychiatry : advancing science from genes to society · 2025Article
- Associations of polygenic risk score, environmental factors, and their interactions with the risk of schizophrenia spectrum disorders.Psychological medicine · 2025Article
- Global research trends on the human exposome: a bibliometric analysis (2005-2024).Environmental science and pollution research international · 2025Review
- Joint modeling of gene-environment correlations and interactions using polygenic risk scores in case-control studies.American journal of epidemiology · 2024Article
- Genome-wide DNA methylation risk scores for schizophrenia derived from blood and brain tissues further explain the genetic risk in patients stratified by polygenic risk scores for schizophrenia and bipolar disorder.BMJ mental health · 2024Article
- Stress, Environment and Early Psychosis.Current neuropharmacology · 2024Review
- Multiomics Analyses Reveal Microbiome-Gut-Brain Crosstalk Centered on Aberrant Gamma-Aminobutyric Acid and Tryptophan Metabolism in Drug-Naïve Patients with First-Episode Schizophrenia.Schizophrenia bulletin · 2024Article
- Study protocol of the Berlin Research Initiative for Diagnostics, Genetics and Environmental Factors in Schizophrenia (BRIDGE-S).BMC psychiatry · 2023Article
- The Effect of Clozapine and Novel Glutamate Modulator JNJ-46356479 on Nitrosative Stress in a Postnatal Murine Ketamine Model of Schizophrenia.International journal of molecular sciences · 2023Article
- Neutrophil to Lymphocyte Ratio in Patients With a First Episode of Psychosis: A Two-Year Longitudinal Follow-up Study.Schizophrenia bulletin · 2022Article
- Risk of psychosis in illicit amphetamine users: a 10 year retrospective cohort study.Evidence-based mental health · 2022Article
- Challenges and Opportunities for Developing More Generalizable Polygenic Risk Scores.Annual review of biomedical data science · 2022Review
- Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients.Schizophrenia (Heidelberg, Germany) · 2022Article
- The Exposome Paradigm to Understand the Environmental Origins of Mental Disorders.Alpha psychiatry · 2021Review
- Estimating Aggregate Environmental Risk Score in Psychiatry: The Exposome Score for Schizophrenia.Frontiers in psychiatry · 2021Review
- Identification ofFrontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
19 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene-environment (GxE) interactions have been related to psychosis spectrum disorders, involving multiple common genetic variants in multiple genes with very small effect sizes, and several environmental factors that constitute a dense network of exposures named the exposome. Here, we aimed to analyze GxE in a cohort of 310 first-episode psychotic (FEP) and 236 healthy controls, by using aggregate scores estimated in large populations such as the polygenic risk score for schizophrenia and (PRS-SCZ) and the Maudsley environmental risk score (ERS). In contrast to previous findings, in our study, the PRS-SCZ did not discriminate cases from controls, but the ERS score explained a similar percentage of the variance as in other studies using similar approaches. Our study supports a positive additive interaction, indicating synergy between genetic susceptibility to schizophrenia (PRS-SCZ dichotomized according to the highest quartile distribution of the control population) and the exposome (ERS > 75% of the controls). This additive interaction showed genetic and environmental dose dependence. Our study shows that the use of aggregate scores derived from large and powered studies instead of statistics derived from specific sample characteristics is a powerful tool for the study of the effects of GxE on the risk of psychotic spectrum disorders. In conclusion, by using a genetic risk score and an ERS we have provided further evidence for the role of GxE in psychosis.
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