ArticleContemporary clinical trials communications2020
Interactive group-based orientation sessions: A method to improve adherence and retention in pragmatic clinical trials.
Article in Contemporary clinical trials communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02113592 (Collaborative Care for Chronic Pain in Primary Care), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Collaborative Care for Chronic Pain in Primary Care
Who cites it
13 citing papers in PubMed.
- Recruitment and retention of emerging adults in lifestyle interventions: Findings from the REACH trial.Contemporary clinical trials · 2022Trial
- Health Without Barriers: Community-Engaged Adaptation of a Whole Family-Inclusive Intensive Health Behavior and Lifestyle Program in Rural Colorado.Prevention science : the official journal of the Society for Prevention Research · 2026Article
- Very Low-Carbohydrate Breakfast Intervention for Adults with Type 2 Diabetes and Persistent Hyperglycemia: Protocol for a Digital, Nonrandomized Pre-Post Study.JMIR research protocols · 2026Article
- Knowledge of Clinical Trials Among US Cancer Survivors: Cross-Sectional Study of HINTS-SEER Data.JMIR cancer · 2025Article
- Feasibility and Acceptability of Behavioral Weight Loss Programs for Men in Trade and Labor Occupations: A Pilot Study.Obesity science & practice · 2025Article
- Review Article: Rome Foundation Working Team Report: Consensus Statement on the Design and Conduct of Behavioural Clinical Trials for Disorders of Gut-Brain Interaction.Alimentary pharmacology & therapeutics · 2025Review
- Design of Project STAR: A randomized controlled trial evaluating the impact of an adaptive intervention on long-term weight-loss maintenance.Contemporary clinical trials · 2024Article
- Casting New Light on Statistical Power: An Illuminating Analogy and Strategies to Avoid Underpowered Trials.American journal of epidemiology · 2022Article
- Article
- Methods-Motivational Interviewing Approach for Enhanced Retention and Attendance.American journal of preventive medicine · 2021Article
- Pilot study of an internet-based pain coping skills training program for patients with systemic Lupus Erythematosus.BMC rheumatology · 2021Article
- Twitter-Based Social Support Added to Fitbit Self-Monitoring for Decreasing Sedentary Behavior: Protocol for a Randomized Controlled Pilot Trial With Female Patients From a Women's Heart Clinic.JMIR research protocols · 2020Article
- Enrollment of Diverse Populations in the INGENIOUS Pharmacogenetics Clinical Trial.Frontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundIntervention adherence and trial retention are challenging for clinical trials testing intensive behavioral interventions. Operational constraints or trial designs may preclude using effective retention strategies such as financial incentives. We examined whether implementing pre-enrollment orientation sessions was associated with higher intervention adherence and retention in a pragmatic clinical trial.
methodsThe trial tested an intensive behavioral intervention for patients with chronic pain on long-term opioids. Orientation sessions were implemented two years into trial recruitment at one site. Held before informed consent and randomization, these mandatory, group-based orientation sessions provided trial specifics, explained research methods principles, and leveraged motivational interviewing techniques. Using a pre-post design and multivariate models, we assessed adherence (number of intervention meetings attended) and retention (completed quarterly pain assessments over 12 months) before (04/2014-12/2015; n = 209) and after (01/2016-02/2017; n = 258) implementation. Also, we evaluated whether session implementation affected the proportion and characteristics of enrolled patients.
resultsAfter implementing orientation sessions, patients had higher intervention adherence than before (M = 7.6, SD = 3.8 vs. M = 5.6, SD = 4.5, respectively; mean difference = 2.0, 95% CI [0.9, 3.2], p = .001), and 2.8 times greater odds of completing quarterly assessments (95% CI [1.3, 5.8], p = .007). Fewer patients enrolled after implementing sessions than before (38.1% vs. 70.8%, 95% CI [26.4, 39.1], p < .001), with no differences in patient characteristics.
conclusionsImplementing orientation sessions during recruitment may be useful for promoting trial adherence and retention. To ensure enrollment goals are met, target population size and barriers affecting patients' ability to attend orientation sessions should be considered, especially for patients with complex medical conditions. CLINICAL TRIALS REGISTRATION NUMBER: NCT02113592.
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