Evidence map›Paper›PMID 32082942›Full record

ArticleInnovations in clinical neuroscience2019

Placental Barrier and Autism Spectrum Disorders: The Roles of Prolactin and Dopamine in the Developing Fetal Brain-Part II.

Atmaram Yarlagadda, Ganesh Acharya, Jayaprada Kasaraneni, Christiane S Hampe, Anita H Clayton

Abstract read
In one paragraph

Article in Innovations in clinical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Atmaram YarlagaddaDr. Yarlagadda is with the Department of Defense and the University of Virginia in Charlottesville, Virginia.
Ganesh AcharyaDr. Yarlagadda is with the Department of Defense and the University of Virginia in Charlottesville, Virginia.
Jayaprada KasaraneniDr. Yarlagadda is with the Department of Defense and the University of Virginia in Charlottesville, Virginia.
Christiane S HampeDr. Yarlagadda is with the Department of Defense and the University of Virginia in Charlottesville, Virginia.
Anita H ClaytonDr. Yarlagadda is with the Department of Defense and the University of Virginia in Charlottesville, Virginia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inverse relationship between prolactin and dopamine is important in the context of treatment with antipsychotic medications in men and nonpregnant women with thought disorders. Likewise, increased levels of prolactin as confirmation of recent seizure and the reciprocal levels of prolactin and dopamine in both eclampsia (seizures) and pre-eclampsia might have significant potential effects on a growing fetus. In this article, we attempt to outline the influence of these associations on autism spectrum disorders (ASDs) in children born to mothers with established diagnoses of eclampsia and/or pre-eclampsia. Our previously published paper, "Placental Barrier and Autism Spectrum Disorders: The Role of Prolactin and Dopamine on the Developing Fetal Brain," summarized evidence for dysregulated dopamine and prolactin levels in the etiology of ASDs and suggested a possible method for assessing whether such aberrations increase the risk of ASDs. The present paper as Part 2 expands on the published data that support this theory and proposes a study design to corroborate this hypothesis.

Indexed as

autismdopamineplacentaprolactin

Identifiers

PMID32082942
PMCPMC7006862

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.