Evidence map›Paper›PMID 32082648›Full record

ArticleCase reports in endocrinology2020

Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia.

Marco Ciacciarelli, Gianluca Caruso, Marco Rengo, Piero Maceroni, Carmen Misurale, Eleonora D'Armiento, Alessandro Polidoro, Cristina Napoli, Alberto Lombardini, Umberto Ceratti and 9 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Marco CiacciarelliDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.ORCID https://orcid.org/0000-0001-7523-0191
Gianluca CarusoDepartment of Medico-Surgical Sciences and Biotechnologies, Pathology Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Marco RengoDepartment of Radiological Sciences, Oncology and Pathology, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.ORCID https://orcid.org/0000-0001-9087-5692
Piero MaceroniDepartment of Radiological Sciences, Oncology and Pathology, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Carmen MisuraleDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Eleonora D'ArmientoDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Alessandro PolidoroDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Cristina NapoliDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Alberto LombardiniDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Umberto CerattiDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Ruben Manuel Luciano Colunga BiancatelliDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Leonardo CalvosaDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Romina MilaneseDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Sonia FerriDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Teresa MassaroDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Andrea LorussoDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Veronica SorrentinoDepartment of Medico-Surgical Sciences and Biotechnologies, Pathology Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Vincenzo PetrozzaDepartment of Medico-Surgical Sciences and Biotechnologies, Pathology Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.
Luigi IulianoDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 1668, Latina 04100, Italy.ORCID https://orcid.org/0000-0002-0027-9326
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient's clinical status deteriorated rapidly, and he died in our department from acute renal failure.

Identifiers

PMID32082648
PMCPMC7019204
OpenAlexW3004372168

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.