ArticleCerebellum & ataxias2020
Oculopalatal tremor following sequential medullary infarcts that did not cause hypertrophic olivary degeneration.
Article in Cerebellum & ataxias, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 10 citations in OpenAlex.
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Multifaceted Mesodiencephalic Triangles: Insights into Hypertrophic Olivary Degeneration and Oculopalatal Tremor Pathophysiology.Cerebellum (London, England) · 2025Review
- Effect of convergence on the horizontal VOR in normal subjects and patients with peripheral and central vestibulopathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Autoimmune Cerebellar Ataxia due to Inflammation of the Inferior Olivary Nuclei.Cerebellum (London, England) · 2021Article
- Clinical and Imaging Profile of Patients with Palatal Tremor.Movement disorders clinical practice · 2021Article
- Palatal Tremor - Pathophysiology, Clinical Features, Investigations, Management and Future Challenges.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Review
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4 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe syndrome of oculopalatal tremor is a known consequence of lesions in the dentate-olivary pathway. Hypertrophic degeneration of the inferior olive is a recognized pathological correlate of these lesions and hypothesized to cause tremorogenic olivary hypersynchrony. However, oculopalatal tremor also occurs in Alexander disease, which produces severe inferior olive degeneration without intervening hypertrophy.
methodsSerial clinical, imaging, video-oculography and kinematic tremor recording of a patient with oculopalatal and limb tremor. CASE STUDY: We report an unusual presentation of oculopalatal tremor and right upper extremity myorhythmia following sequential right dorsolateral and left anteromedial medullary infarcts directly involving both inferior olives. As in adult Alexander disease, our patient did not have hypertrophic olivary degeneration during 10 years of follow-up.
conclusionContemporary theories have emphasized the role of cerebellar maladaptation in "shaping" oscillations generated elsewhere, the inferior olive in particular. Our patient and published Alexander disease cases illustrate that oculopalatal tremor can occur in the absence of hypertrophic olivary degeneration. Therefore, cerebellar maladaptation to any form of olivary damage may be the critical pathophysiology in producing oculopalatal tremor.
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