ReviewDiabetology & metabolic syndrome2020
Mechanism of increased risk of insulin resistance in aging skeletal muscle.
Review in Diabetology & metabolic syndrome, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
155 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Unraveling the role of muscle mass and strength in predicting type 2 diabetes risk: a systematic review.Acta diabetologica · 2025Pooled it
- Prognostic Impact and Prevalence of Cachexia in Patients With Heart Failure: A Systematic Review and Meta-Analysis.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Trial
- Association of predicted lean body mass and fat mass with prognosis in patients with heart failure preserved ejection fraction.PloS one · 2025Trial
- Age-Specific Associations of Moderate-to-Vigorous Physical Activity With Relative and Absolute Risk of Type 2 Diabetes in UK Biobank Participants.Diabetes, obesity & metabolism · 2026Article
- Leg fat-to-total fat ratio improves waist-to-height ratio for discriminating metabolic syndrome: a nationwide cross-sectional study.Journal of endocrinological investigation · 2026Article
- Article
- Fiber type specific tibialis anterior muscle atrophy and oxidative capacity reduction is contemporaneous with death of larger lumbar motor neurons in old rats.Physiological reports · 2026Article
- Intermittent Fasting and Fat-Free Mass Outcomes in Middle-Aged and Older Adults: A Scoping Review.Advances in nutrition (Bethesda, Md.) · 2026Article
- Interplay between sarcopenia and type 2 diabetes: mechanisms, implications, and therapeutic prospects.Nutrition & diabetes · 2026Review
- Continuous glucose monitoring as a tool in early-stage type 1 diabetes.Diabetologia · 2026Review
- Waist circumference and grip strength and their joint relations to type 2 diabetes incidence in UK Biobank.BMC medicine · 2026Article
- Sarcopenia and physical performance among older adults with increased body mass index and falls.Scientific reports · 2026Article
- Hypothesis: Nutrient Off-Loading and Ectopic Fat Reduction Reverse Insulin Resistance and Improve Cardiovascular Outcomes in Type 2 Diabetes-A Narrative Review.International journal of molecular sciences · 2026Review
- Plasma extracellular vesicle signatures of metabolic health and exercise response in a pilot study of older adults.American journal of physiology. Cell physiology · 2026Article
- Predictors of glycemic control with imeglimin for type 2 diabetes: Results of machine learning analyses using clinical trial data.Journal of diabetes investigation · 2026Article
- Sarcopenia in Aging: Pathogenesis, Diagnosis, and Emerging Therapeutic Frontiers.Molecular imaging and biology · 2026Review
- Malnutrition-Sarcopenia Syndrome in older adults: Causes, consequences, and countermeasures.EXCLI journal · 2026Review
- Triglyceride-glucose index and atherogenic index of plasma as predictors of cardiovascular risk in rectal cancer survivors.Frontiers in cardiovascular medicine · 2026Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As age increases, the risk of developing type 2 diabetes increases, which is associated with senile skeletal muscle dysfunction. During skeletal muscle aging, mitochondrial dysfunction, intramyocellular lipid accumulation, increased inflammation, oxidative stress, modified activity of insulin sensitivity regulatory enzymes, endoplasmic reticulum stress, decreased autophagy, sarcopenia and over-activated renin-angiotensin system may occur. These changes can impair skeletal muscle insulin sensitivity and increase the risk of insulin resistance and type 2 diabetes during skeletal muscle aging. This review of the mechanism of the increased risk of insulin resistance during skeletal muscle aging will provide a more comprehensive explanation for the increased incidence of type 2 diabetes in elderly individuals, and will also provide a more comprehensive perspective for the prevention and treatment of type 2 diabetes in elderly populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.