ArticleImmunity & ageing : I & A2020
A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation.
Article in Immunity & ageing : I & A, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Thymic health and implications for chronic kidney disease.Nature reviews. Nephrology · 2026Article
- Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Immunosuppression after pediatric liver transplantation may lead to early and prolonged acute thymic involution: findings from a pilot longitudinal study.Frontiers in immunology · 2026Article
- Cellular Immunity in Chronic Kidney Disease and Changes After Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Kidney Transplantation and Cellular Immunity Dynamics: Immune Cell Alterations and Association with Clinical and Laboratory Parameters.Journal of clinical medicine · 2024Article
- Multi-organ single-cell transcriptomics of immune cells uncovered organ-specific gene expression and functions.Scientific data · 2024Article
- COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review.Biomedicines · 2023Review
- Decreased thymic output predicts progression of chronic kidney disease.Immunity & ageing : I & A · 2023Article
- Lowering maintenance immune suppression in elderly kidney transplant recipients; connecting the immunological and clinical dots.Frontiers in medicine · 2023Review
- The Incidence of Antibody-Mediated Rejection Is Age-Related, Plateaus Late After Kidney Transplantation, and Contributes Little to Graft Loss in the Older Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Causes of Kidney Graft Failure in a Cohort of Recipients With a Very Long-Time Follow-Up After Transplantation.Frontiers in medicine · 2022Article
- Editorial: Immunosenescence and Immunoexhaustion in Chronic Kidney Disease and Renal Transplantation.Frontiers in medicine · 2022Article
- Hallmarks of T cell aging.Nature immunology · 2021Review
- Uremia-Associated Immunological Aging and Severity of COVID-19 Infection.Frontiers in medicine · 2021Review
- Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnd-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was tested that advanced immunological T cell ageing assessed by peripheral T cell differentiation increases the long-term mortality risk after renal transplantation.
resultsCirculating T cells of 211 recipients of a kidney from a living donor were analyzed before and in the first year after transplantation. The number of CD31-positive naive T cells (as a marker for recent thymic emigrants) and the differentiation status of the memory T cells was assessed. Thirty recipients died during follow-up of at least 5 years. Absolute numbers of naive CD4
conclusionsA severe reduction in circulating naïve T cells because of a decrease in recent thymic emigrants is highly associated with all-cause mortality after renal transplantation.
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